Document Detail

Heart rate and blood pressure control in infants exposed to maternal cigarette smoking.
MedLine Citation:
PMID:  18691163     Owner:  NLM     Status:  MEDLINE    
AIM: Exposure to maternal cigarette smoking is a major risk factor for sudden infant death syndrome (SIDS). Foetal and postnatal smoke-exposure may alter cardiovascular control in infants. We studied heart rate (HR) and blood pressure (BP) responses in smoke-exposed infants. METHODS: Eleven infants exposed to maternal cigarette smoking were studied at the age of 12 +/- 2.1 (range 10-16) weeks. Twenty healthy, age-matched infants from non-smoking families served as controls. During confirmed slow-wave sleep (NREM3), 3-5 sec side motion and 45 sec 45 degrees head-up tilt tests were performed. RESULTS: Control infants showed consistent biphasic HR and BP responses to side motion, with an initial 2-5% increase followed by a 2% decrease (p < 0.0001). In smoke-exposed infants, the initial HR (p = 0.009) and BP responses (p < 0.0001) were markedly reduced, and the subsequent decrease in BP was more prominent (systolic blood pressure, SBP, p = 0.005; diastolic blood pressure, DBP, p = 0.03). No differences were observed between the groups in tilt test results, HR variability or HR responses to spontaneous arousals. CONCLUSION: Maternal cigarette smoking may alter vestibulo-mediated cardiovascular control in early infancy. This may contribute to increased SIDS risk.
S Viskari-Lähdeoja; T Hytinantti; S Andersson; T Kirjavainen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-06
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1535-41     Citation Subset:  IM    
Hospital for Children and Adolescents, Helsinki, Finland.
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MeSH Terms
Blood Pressure*
Case-Control Studies
Heart Rate*
Maternal Behavior
Maternal Exposure / adverse effects*
Risk Factors
Smoking / adverse effects*
Sudden Infant Death / etiology
Vestibular Function Tests*

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