Document Detail

Heart rate is associated with red blood cell fatty acid concentration: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.
MedLine Citation:
PMID:  20569715     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Consumption of omega-3 fatty acids (FAs) is associated with a reduction in deaths from coronary heart disease, arrhythmia, and sudden death. Although these FAs were originally thought to be antiatherosclerotic, recent evidence suggests that their benefits are related to reducing risk for ventricular arrhythmia and that this may be mediated by a slowed heart rate (HR).
METHODS: The study was conducted in Alaskan Eskimos participating in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study, a population experiencing a dietary shift from unsaturated to saturated fats. We compared HR with red blood cell (RBC) FA content in 316 men and 391 women ages 35 to 74 years.
RESULTS: Multivariate linear regression analyses of individual FAs with HR as the dependent variable and specific FAs as covariates revealed negative associations between HR and docosahexaenoic acid (22:6n-3; P = .004) and eicosapentaenoic acid (20:5n-3; P = .009) and positive associations between HR and palmitoleic acid (16:1n-7; P = .021), eicosanoic acid (20:1n9; P = .007), and dihomo-gamma-linolenic acid (DGLA; 20:3n-6; P = .021). Factor analysis revealed that the omega-3 FAs were negatively associated with HR (P = .003), whereas a cluster of other, non-omega-3 unsaturated FAs (16:1, 20:1, and 20:3) was positively associated.
CONCLUSIONS: Marine omega-3 FAs are associated with lower HR, whereas palmitoleic and DGLA, previously identified as associated with saturated FA consumption and directly related to cardiovascular mortality, are associated with higher HR. These relations may at least partially explain the relations between omega-3 FAs, ventricular arrhythmia, and sudden death.
Sven O E Ebbesson; Richard B Devereux; Shelley Cole; Lars O E Ebbesson; Richard R Fabsitz; Karin Haack; William S Harris; Wm James Howard; Sandra Laston; Juan Carlos Lopez-Alvarenga; Jean W MacCluer; Peter M Okin; M Elizabeth Tejero; V Saroja Voruganti; Charlotte R Wenger; Barbara V Howard; Anthony G Comuzzie
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American heart journal     Volume:  159     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-15     Revised Date:  2014-04-23    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1020-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Alaska / epidemiology
Coronary Artery Disease / blood,  ethnology,  genetics*
Death, Sudden, Cardiac / ethnology,  etiology
Erythrocytes / metabolism*
Fatty Acids, Omega-3 / adverse effects,  blood*,  pharmacokinetics
Follow-Up Studies
Genetic Predisposition to Disease*
Heart Rate / physiology*
Middle Aged
Retrospective Studies
Risk Factors
Tachycardia, Ventricular / blood,  ethnology,  etiology
Grant Support
M10RR0047-34/RR/NCRR NIH HHS; R01-HL64244/HL/NHLBI NIH HHS; U01 HL064244/HL/NHLBI NIH HHS; U01 HL064244-05/HL/NHLBI NIH HHS; U01 HL064244-06/HL/NHLBI NIH HHS; U01 HL064244-07/HL/NHLBI NIH HHS; U01 HL064244-07S1/HL/NHLBI NIH HHS; U01 HL064244-08/HL/NHLBI NIH HHS; U01 HL064244-09/HL/NHLBI NIH HHS; U01 HL064244-09S1/HL/NHLBI NIH HHS; U01 HL064244-10/HL/NHLBI NIH HHS; U01 HL082458/HL/NHLBI NIH HHS; U01 HL082458-01/HL/NHLBI NIH HHS; U01 HL082458-02/HL/NHLBI NIH HHS; U01 HL082458-03/HL/NHLBI NIH HHS; U01 HL082458-04/HL/NHLBI NIH HHS; U01 HL082458-05/HL/NHLBI NIH HHS; U01 HL082490/HL/NHLBI NIH HHS; U01 HL082490-01/HL/NHLBI NIH HHS; U01 HL082490-02/HL/NHLBI NIH HHS; U01 HL082490-03/HL/NHLBI NIH HHS; U01 HL082490-04/HL/NHLBI NIH HHS; U01 HL082490-05/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3

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