Document Detail


Heart rate as a predictor of first-trimester spontaneous abortion after ultrasound-proven viability.
MedLine Citation:
PMID:  1876359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To discover whether first-trimester spontaneous abortion can be predicted by embryonic heart rate (EHR), we performed a cross-sectional study during the first trimester of pregnancy using high-frequency transvaginal sonography combined with pulsed Doppler. Heart rate was measured in 603 embryos; of these, 580 continued beyond 13 weeks' gestation and 23 ended in first-trimester spontaneous abortion. Based on the continuing pregnancies, we constructed and compared EHR nomograms relating to gestational age, mean diameter of the gestational sac, and crown-rump length (CRL). Embryonic heart rate correlated best with CRL (r = 0.87), and the correlation was best described by a second-degree polynomial regression equation. The mean EHR increased progressively from 110 beats per minute (bpm) at CRL of 3-4 mm to 171-178 bpm at CRL 15-32 mm. At CRL greater than 32 mm, the EHR remained stable at a mean of 170 bpm. The EHRs of the 23 embryos that spontaneously aborted in the first trimester were evaluated according to these nomograms. In 15 cases, the EHR fell outside the 95% confidence interval for CRL (sensitivity 65%), but it was within normal limits in eight (false-negative rate 35%). In ten embryos for which pregnancy continued beyond 13 weeks, the EHR fell outside the 95% confidence interval (specificity 98%, false-positive rate 2%). Our findings suggest that EHR measurements in early pregnancy may be useful in the prediction of first-trimester spontaneous abortion after ultrasound-proven viability.
Authors:
R Achiron; O Tadmor; S Mashiach
Related Documents :
8719349 - Growth in the lateral part of the human skull during the second trimester.
11702919 - The level of accuracy and agreement in measures of feo2, feco2 and ve between the cosme...
9793189 - Growth of the fetal orbit and lens in normal pregnancies.
9784639 - A case of congenital familial short femur diagnosed prenatally.
21602839 - Maternal-fetal fluid balance and aquaporins: from molecule to physiology.
8264019 - Predicting pregnancy survival from a single first trimester vaginal ultrasonogram.
21500199 - Periovulatory follicular volume and vascularization determined by 3d and power doppler ...
20926839 - Asymmetric syncytial expression of glut9 splice variants in human term placenta and alt...
17688309 - Computerized fetal heart rate analysis, doppler ultrasound and biophysical profile scor...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology*
Cross-Sectional Studies
Female
Fetal Viability*
Fetus / anatomy & histology
Heart Rate, Fetal*
Humans
Observer Variation
Predictive Value of Tests
Pregnancy
Reference Values
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The relationship between recent cocaine use and pregnancy outcome.
Next Document:  Multifetal reduction of triplets and pregnancy outcome.