Document Detail

Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study.
MedLine Citation:
PMID:  16915038     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Whether heart rate predicts the development of sustained hypertension in individuals with hypertension is not well known. We carried out a prospective study to investigate whether clinic and ambulatory heart rates assessed at baseline and changes in clinic heart rate during 6 months of follow-up were independent predictors of subsequent blood pressure (BP). METHODS: The study was conducted in a cohort of 1103 white, stage 1 hypertensive individuals from the HARVEST study, never treated for hypertension and followed-up for an average of 6.4 years. Data were adjusted for baseline BP, age, sex, body fatness, physical activity habits, parental hypertension, duration of hypertension, cigarette smoking, alcohol consumption, and change of body weight from baseline. RESULTS: Clinic heart rate and heart rate changes during the first 6 months of follow-up were independent predictors of subsequent systolic blood pressure (SBP) and diastolic blood pressure (DBP) regardless of initial BP and other confounders (all P < 0.01). A significant interaction was found between sex (male) and baseline resting heart rate on final SBP (P = 0.017) and DBP (P < 0.001). The ambulatory heart rate and the heart rate white-coat effect did not add prognostic information to that provided by the clinic heart rate. Patients whose heart rate was persistently elevated during the study had a doubled fully adjusted risk (95% confidence interval 1.4-2.9) of developing sustained hypertension in comparison with subjects with a normal heart rate. CONCLUSIONS: Baseline clinic heart rate and heart rate changes during the first few months of follow-up are independent predictors of the development of sustained hypertension in young persons screened for stage 1 hypertension.
Paolo Palatini; Francesca Dorigatti; Vania Zaetta; Paolo Mormino; Adriano Mazzer; Alessandra Bortolazzi; Daniele D'Este; Fabrizio Pegoraro; Loredano Milani; Lucio Mos;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-17     Completed Date:  2007-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1873-80     Citation Subset:  IM    
Clinica Medica 4, University of Padova, Padua, Italy.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Autonomic Nervous System / metabolism
Blood Pressure
Heart Rate*
Hypertension / diagnosis*,  pathology*
Middle Aged
Risk Factors
Sex Factors
Signal Transduction
Reg. No./Substance:
0/Antihypertensive Agents
Comment In:
J Hypertens. 2006 Sep;24(9):1711-3   [PMID:  16915018 ]

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