Document Detail

Heart and liver fatty acid binding proteins and the metabolic syndrome.
MedLine Citation:
PMID:  16386194     Owner:  NLM     Status:  MEDLINE    
Cytosolic fatty acid binding proteins (FABPs) are widely expressed fatty acid chaperones. The adipocyte-expressed FABPs are permissive factors for the fat-induced metabolic syndrome, but a similar relevance of the FABPs of heart, muscle, and liver remains unclear. In this article, the known biochemical and physiologic roles of these FABPs are discussed in this context. It is concluded that the observations on adipocyte-expressed FABPs cannot be automatically extended to other tissues. More work is needed to clarify whether the individual or combined inhibition of FABPs is a desirable strategy to treat the metabolic syndrome.
Bert Binas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  7     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-02     Completed Date:  2006-05-04     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, Raymond Stotzer Parkway, College Station, TX 77843, USA.
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MeSH Terms
Biological Markers / metabolism
Cytosol / metabolism
Fatty Acid-Binding Proteins / metabolism*
Liver / metabolism*
Metabolic Syndrome X / metabolism*
Myocardium / metabolism*
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acid-Binding Proteins

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