| Heart and liver T2* assessment for iron overload using different software programs. | |
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MedLine Citation:
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PMID: 21842212 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the level of agreement and interchangeability among different software programs for calculation of T2* values for iron overload. METHODS: T2* images were analysed in 60 patients with thalassaemia major using the truncation method in three software programs. Levels of agreement were assessed using Pearson correlation and Bland-Altman plots. Categorical classification for levels of iron concentration by each software program was also compared. RESULTS: For the heart, all correlation coefficients were significant among the software programs (P < 0.001 for all coefficients). The mean differences and 95% limits of agreement were 0.2 (-4.73 to 5.0); 0.1 (-4.0 to 3.9); and -0.1 (-4.3 to 4.8). For the liver all correlations were also significant with P < 0.001. Bland-Altman plots showed differences of -0.02 (-0.7 to 0.6); 0.01 (-0.4 to 0.4); and -0.02 (-0.6 to 0.6). There were no significant differences in clinical classification among the software programs. CONCLUSIONS: All tools used in this study provided very good agreement among heart and liver T2* values. The results indicate that interpretation of T2* data is interchangeable with any of the software programs tested. KEY POINTS: Magnetic resonance imaging in iron overload assessment has become an essential tool. Post processing options to establish T2* values have not been compared. No differences were found on T2* of the liver or heart using 3 different techniques. Availability of these methods should allow more widespread interpretation of iron overload by MRI. |
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Authors:
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Juliano L Fernandes; Erika Fontana Sampaio; Monica Verissimo; Fabricio B Pereira; Jose Alvaro da Silva; Gabriel S de Figueiredo; Jose M Kalaf; Otavio R Coelho |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-13 |
Journal Detail:
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Title: European radiology Volume: - ISSN: 1432-1084 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Campinas, Unicamp, Campinas, Brazil, jlaraf@fcm.unicamp.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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