Document Detail

Heart, kidney, and intestine have different tolerances for anemia.
MedLine Citation:
PMID:  18201678     Owner:  NLM     Status:  MEDLINE    
Organ systems do not respond uniformly to changes in systemic oxygen delivery because of global and local redistributive mechanisms. We hypothesized that progressive hemodilution would evoke a different response in the microvascular oxygenation of the heart compared with kidney and gut. To evaluate this hypothesis, we studied the effect of stepwise isovolemic hemodilution on systemic hemodynamic and oxygenation parameters as well as the relation between systemic hematocrit (Ht) and microvascular PO(2) (microPO(2)) in heart, kidney, and intestines in an anesthetized and mechanically ventilated rat model. Baseline conditions were similar in the hemodilution group and in the control group. In the hemodilution group, Ht was diminished from 46.6 +/- 3.8% to 7.0 +/- 1.8% [mean +/- standard deviation (SD)]. This group had no effect on measured hemodynamics; only when Ht fell below 10% did blood pressure start to decrease. The microPO(2) values in heart, kidney, and intestines did not respond uniformly. Renal microPO(2) (56 +/- 10 mm Hg at baseline) started to decrease at a Ht of 38.5 +/- 8.6%, whereas intestinal microPO(2) (59 +/- 6 mm Hg at baseline) did not start to decrease until Ht reached 17.4 +/- 7.1%. Finally, cardiac microPO(2) (40 +/- 6 mm Hg at baseline) decreased only in the ultimate stage of the experiment at Ht of 8.7 +/- 3.5%. Based on these observations, we conclude that the regulation of microvascular oxygenation during progressive anemia is specific for each organ system. The relation between these observations and organ function and damage needs to be determined.
Jasper van Bommel; Martin Siegemund; Ch Pieter Henny; Can Ince
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Publication Detail:
Type:  Journal Article     Date:  2007-12-17
Journal Detail:
Title:  Translational research : the journal of laboratory and clinical medicine     Volume:  151     ISSN:  1931-5244     ISO Abbreviation:  Transl Res     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-03-04     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  101280339     Medline TA:  Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-7     Citation Subset:  AIM; IM    
Department of Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands.
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MeSH Terms
Anemia / metabolism*,  physiopathology
Blood Gas Analysis
Capillaries / metabolism
Coronary Vessels / metabolism
Disease Models, Animal
Hemodilution / adverse effects
Intestines / blood supply,  metabolism*
Kidney / blood supply,  metabolism*
Myocardium / metabolism*
Oxygen / metabolism
Oxygen Consumption
Rats, Wistar
Reg. No./Substance:

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