Document Detail


Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke.
MedLine Citation:
PMID:  16035729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart-fatty acid-binding protein (H-FABP) is a small cytosolic protein involved in intracellular fatty acid transport. This protein, highly concentrated in the heart, is quickly released into plasma after myocardial injury. Results from numerous studies suggest that H-FABP is an excellent marker for the early detection of myocardial damage. H-FABP is also expressed in the brain, although in lower concentrations than in the heart. Recent preliminary studies also investigated the usefulness of H-FABP for the diagnosis of acute and chronic neurological disorders. These potential applications of H-FABP in clinical practice are reviewed in this article, with a strong focus on the early diagnosis of acute myocardial infarction and stroke.
Authors:
Pierre Lescuyer; Laure Allard; Denis F Hochstrasser; Jean-Charles Sanchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology     Volume:  9     ISSN:  1084-8592     ISO Abbreviation:  Mol. Diagn.     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9614965     Medline TA:  Mol Diagn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Bioinformatics and Structural Biology, Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland. Pierre.Lescuyer@medecine.unige.ch
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Biological Markers / analysis
Brain Injuries / diagnosis
Carrier Proteins / analysis*
Early Diagnosis
Fatty Acid-Binding Proteins
Humans
Myocardial Infarction / diagnosis*
Neurodegenerative Diseases / diagnosis
Stroke / diagnosis*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/Fatty Acid-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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