Document Detail

Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke.
MedLine Citation:
PMID:  16035729     Owner:  NLM     Status:  MEDLINE    
Heart-fatty acid-binding protein (H-FABP) is a small cytosolic protein involved in intracellular fatty acid transport. This protein, highly concentrated in the heart, is quickly released into plasma after myocardial injury. Results from numerous studies suggest that H-FABP is an excellent marker for the early detection of myocardial damage. H-FABP is also expressed in the brain, although in lower concentrations than in the heart. Recent preliminary studies also investigated the usefulness of H-FABP for the diagnosis of acute and chronic neurological disorders. These potential applications of H-FABP in clinical practice are reviewed in this article, with a strong focus on the early diagnosis of acute myocardial infarction and stroke.
Pierre Lescuyer; Laure Allard; Denis F Hochstrasser; Jean-Charles Sanchez
Related Documents :
18454579 - Urgent need for secondary stroke prevention after transient ischemic attack.
16201719 - Ischaemic stroke in jordan: a 2-year hospital-based study of subtypes and risk factors.
19682409 - Epileptiform discharges and neuronal plasticity in the acute peri-infarct cortex of rats.
11246539 - Activation products of the haemostatic system in coronary, cerebrovascular and peripher...
15845889 - Chagasic cardiomyopathy is independently associated with ischemic stroke in chagas dise...
16888379 - Predictors of cerebral microbleeds in acute ischemic stroke and tia patients.
15316309 - Isolated right ventricular failure in scleroderma heart disease.
16245959 - Prevention of cardiovascular events in elderly people.
11286379 - Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology     Volume:  9     ISSN:  1084-8592     ISO Abbreviation:  Mol. Diagn.     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9614965     Medline TA:  Mol Diagn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Bioinformatics and Structural Biology, Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Biological Markers / analysis
Brain Injuries / diagnosis
Carrier Proteins / analysis*
Early Diagnosis
Fatty Acid-Binding Proteins
Myocardial Infarction / diagnosis*
Neurodegenerative Diseases / diagnosis
Stroke / diagnosis*
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/Fatty Acid-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Arthritis in the older person: Part 2.
Next Document:  Paraoxonase 1-192Q allele is a risk factor for idiopathic chronic pancreatitis.