| Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke. | |
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MedLine Citation:
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PMID: 16035729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart-fatty acid-binding protein (H-FABP) is a small cytosolic protein involved in intracellular fatty acid transport. This protein, highly concentrated in the heart, is quickly released into plasma after myocardial injury. Results from numerous studies suggest that H-FABP is an excellent marker for the early detection of myocardial damage. H-FABP is also expressed in the brain, although in lower concentrations than in the heart. Recent preliminary studies also investigated the usefulness of H-FABP for the diagnosis of acute and chronic neurological disorders. These potential applications of H-FABP in clinical practice are reviewed in this article, with a strong focus on the early diagnosis of acute myocardial infarction and stroke. |
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Authors:
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Pierre Lescuyer; Laure Allard; Denis F Hochstrasser; Jean-Charles Sanchez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology Volume: 9 ISSN: 1084-8592 ISO Abbreviation: Mol. Diagn. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-07-22 Completed Date: 2005-10-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9614965 Medline TA: Mol Diagn Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Bioinformatics and Structural Biology, Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland. Pierre.Lescuyer@medecine.unige.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Biological Markers / analysis Brain Injuries / diagnosis Carrier Proteins / analysis* Early Diagnosis Fatty Acid-Binding Proteins Humans Myocardial Infarction / diagnosis* Neurodegenerative Diseases / diagnosis Stroke / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Carrier Proteins; 0/Fatty Acid-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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