| Heart failure with preserved versus reduced left ventricular systolic function: a prospective cohort of Shinken Database 2004-2005. | |
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MedLine Citation:
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PMID: 20122556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several hospital-based investigations have reported that a high proportion of patients with heart failure (HF) have preserved left ventricular ejection fraction (LVEF). The purpose of this study was to determine the prevalence, prognosis, and predictors for mortality of Japanese HF patients with preserved versus reduced LVEF in a prospective cohort fashion. METHODS AND RESULTS: Our hospital-based database including inpatients and also outpatients was used for analysis. Out of 4255 new patients, 597 patients (male/female 414/183, age 65.1+/-12.9 years) were diagnosed as having symptomatic HF at the initial visit. Among 589 HF patients undergoing echocardiography, 398 (67.6%) showed a preserved LVEF (>50%) and 191 (32.4%) had a reduced LVEF (< or =50%). Patients with preserved LVEF were older (p=0.004) and more likely to be female (p=0.002). During follow-up of an average 539 days, 34 cardiovascular deaths occurred, and patients with preserved LVEF showed a better prognosis than those with reduced LVEF (3.2% vs. 7.4% per year, p=0.0097). Multivariate Cox hazards analysis identified LVEF as an independent predictor in all HF patients. Also, separated group analysis showed that presence of chronic kidney disease was independently associated with poor prognosis irrespective of HF types. CONCLUSIONS: This prospective cohort study identified prevalence and prognosis of HF in Japanese in- and outpatients, where patients with preserved LVEF showed a better prognosis than those with reduced LVEF. |
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Authors:
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Ayumi Goda; Takeshi Yamashita; Shinya Suzuki; Takayuki Ohtsuka; Tokuhisa Uejima; Yuji Oikawa; Junji Yajima; Akira Koike; Kazuyuki Nagashima; Hajime Kirigaya; Koichi Sagara; Ken Ogasawara; Mitsuaki Isobe; Hitoshi Sawada; Tadanori Aizawa |
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Publication Detail:
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Type: Journal Article Date: 2009-12-21 |
Journal Detail:
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Title: Journal of cardiology Volume: 55 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 108-16 Citation Subset: IM |
Copyright Information:
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2009 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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The Cardiovascular Institute, Tokyo, Japan. ayumi-go@cvi.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Echocardiography Electrocardiography Female Heart Failure / epidemiology, mortality*, physiopathology Humans Kidney Failure, Chronic / complications Male Prognosis Prospective Studies Risk Factors Stroke Volume / physiology* Systole / physiology Ventricular Function, Left / physiology |
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