Document Detail

Heart failure with preserved ejection fraction.
MedLine Citation:
PMID:  25468914     Owner:  NLM     Status:  In-Data-Review    
Many patients with heart failure (HF) have a normal left ventricular ejection fraction, and are labelled as having HF with preserved left ventricular ejection fraction (HFPEF). Hypertension, atrial fibrillation and age are important contributors to the development of HFPEF and, therefore, its prevalence is likely to increase in the next few decades. The pathophysiology of HFPEF is heterogeneous but with a final common pathway leading to congestion. HF remains a clinical diagnosis but the plasma concentration of B-type natriuretic peptide (eg BNP/N-terminal prohormone BNP (NT-proBNP)), a marker of congestion, is an essential component. Imaging, usually by echocardiography, is required to determine the cardiac phenotype (ie valve disease, left ventricular ejection fraction) underlying HF. A superficially normal echocardiogram does not exclude a diagnosis of HF. No treatment has been shown conclusively to alter the prognosis of HFPEF. However, treatments directed at congestion and hypertension, such as diuretics, mineralocorticoid receptor antagonists (MRAs) and angiotensin converting-enzyme inhibitors, may improve symptoms and probably do improve outcomes. No treatment has yet been shown to reverse the underlying myocardial pathology of HFPEF, although there is some hope that MRAs might.
Pierpaolo Pellicori; John Gf Cleland
Related Documents :
22093194 - Lv twisting and untwisting in hcm: ejection begets filling diastolic functional aspects...
25388894 - Beating heart myocardial revascularisation of a sudden cardiac death survivor with spon...
25378974 - Effects of intensive versus mild lipid lowering by statins in patients with ischemic co...
25481934 - Left ventricular systolic dysfunction in chronic kidney disease: from asymptomatic chan...
24294034 - Cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis.
1540444 - Need for invasive cardiological assessment and intervention: a ten year review.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical medicine (London, England)     Volume:  14 Suppl 6     ISSN:  1470-2118     ISO Abbreviation:  Clin Med     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092853     Medline TA:  Clin Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  s22-8     Citation Subset:  IM    
Copyright Information:
© 2014 Royal College of Physicians.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Host genetic factors in susceptibility to mycobacterial disease.
Next Document:  Thyroid disease and vascular risk.