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Heart failure with preserved ejection fraction: an ongoing enigma.
MedLine Citation:
PMID:  24286586     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome based on traditional heart failure symptoms with documentation of increased left ventricular filling pressures and preserved left ventricular ejection fraction. The exact mechanisms that induce HFpEF are not known. End-diastolic ventricular stiffness does not seem to be acting alone. Substantial mortality exists compared with healthy age-matched controls, as well as significant health care expenditures on hospitalizations and readmissions. This article reviews the epidemiology, pathophysiology, and treatment of heart failure with preserved ejection fraction (HFpEF). Current practice guidelines focus on remedying volume overload, aggressively controlling hypertension, and treatment of comorbid conditions that contribute to decompensation.
Authors:
Lisa J Rose-Jones; John J Rommel; Patricia P Chang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology clinics     Volume:  32     ISSN:  1558-2264     ISO Abbreviation:  Cardiol Clin     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2013-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill, 160 Dental Circle, 6th Floor Burnett-Womack Building, Chapel Hill, NC 27599-7075, USA.
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