| Heart failure with a preserved ejection fraction additive value of an exercise stress echocardiography. | |
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MedLine Citation:
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PMID: 22291430 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Heart failure (HF) with a preserved (P) left ventricular (LV) ejection fraction (EF) is common, though its diagnosis and physiopathology remains unclear. We sought to analyse the myocardial characteristics at rest and during a sub-maximal exercise test in patients with HFPEF. METHODS AND RESULTS: Standardized sub-maximal exercise stress echocardiography was performed in (i) 21 patients from the Karolinska Rennes Prospective Study of Heart Failure with Preserved Left Ventricular Ejection Fraction HFPEF registry, whose LVEF was ≥45% and (ii) 15 control patients free of any manifestations of HF. During a sub-maximal exercise test, LV systolic function measured as a global four-chamber longitudinal strain was -17 ± 5% in patients with HFPEF vs. -22 ± 4% in controls (P < 0.001), LV longitudinal diastolic relaxation, expressed as e' (septal and lateral walls averaged) was 9 ± 2 cm/s in patients vs. 15 ± 4 cm/s in controls (P < 0.001), and RV longitudinal systolic function, expressed as RV s', was 14 ± 3 cm/s in patients vs. 18±1 cm/s in controls (P = 0.03). LV afterload (arterial elastance) was 2.7 ± 1 mmHg/mL and was correlated with a decrease in LV longitudinal strain (R = 0.51, P < 0.01) during exercise. CONCLUSION: The assessment of longitudinal systolic and diastolic LV and RV functions is valuable during a sub-maximal exercise stress echocardiography to confirm the heart dysfunction related to the HFPEF symptoms. It might be used as a diagnostic test for difficult clinical situations.ClinicalTrials.gov identifier: NCT01091467. |
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Authors:
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Erwan Donal; Christophe Thebault; Lars H Lund; Gaëlle Kervio; Amelie Reynaud; Tabasomne Simon; Elodie Drouet; Emilie Nonotte; Cecilia Linde; Jean-Claude Daubert |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-29 |
Journal Detail:
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Title: European heart journal cardiovascular Imaging Volume: - ISSN: 2047-2412 ISO Abbreviation: Eur Heart J Cardiovasc Imaging Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101573788 Medline TA: Eur Heart J Cardiovasc Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiology, Pontchaillou University Hospital, 2 Rue Henri Le Guilloux, 35033 Rennes, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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