Document Detail


Heart failure and thyroid dysfunction.
MedLine Citation:
PMID:  22956554     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACTCONTEXT: Heart failure is a major cause of morbidity and mortality in Europe and in the United States .The aim of this review article was to assess the results of the prospective studies that evaluated the risk of heart failure in patients with overt and subclinical thyroid disease and to discuss the mechanism of this dysfunction. EVIDENCE ACQUISITION: Reports published with the following search terms :thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism , levothyroxine, triiodothyronine, antithyroid drugs, radioiodine , deiodinases, clinical symptoms, heart rate, heart failure, systolic function , diastolic function, systemic vascular resistance , endothelial function, amiodarone, atrial fibrillation, were searched. The investigation was restricted to reports published in English. EVIDENCE SYNTHESIS: The outcome of this analysis suggests that patients with overt and subclinical thyroid dysfunction are at increased risk of heart failure. In particular, this risk is increased in elderly patients with subclinical thyroid disease and serum TSH <0.1mU/L or >10 mU/L . CONCLUSIONS: The timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction.
Authors:
Bernadette Biondi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-6
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
B Biondi, Dept of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, 80131, Italy.
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