Document Detail

Heart failure: molecular, genetic and epigenetic features of the disease.
MedLine Citation:
PMID:  23147437     Owner:  NLM     Status:  In-Data-Review    
Factors that compete to establish heart failure (HF) are not completely known. In the last years the several technological improvements allowed us to deeply study the molecular and genetic aspects of this complex syndrome. This new approach to HF based on molecular biology new discoveries shows us more clearly the pathophysiological bases of this disease, and a future scenery where the genetics may be useful in the clinical practice, as screening of high risk populations, as well as in the diagnosis and therapy of underlying myocardial diseases. The purpose of this review was to analyse the molecular, genetic and epigenetic factors of HF. We described the molecular anatomy of the sarcomere and the pathogenesis of the heart muscle diseases, abandoning the previous monogenic theory for the concept of a polygenic disease. Different actors play a role to cause the illness by themselves, modifying the expression of the disease and, eventually, the prognosis of the patient.
R D'Alessandro; T Roselli; F Valente; M Iannaccone; C Capogrosso; G Petti; G Alfano; D Masarone; B Ziello; F Fimiani; G Pacileo; M G Russo; P Calabrò; G Limongelli; V Maddaloni; R Calabrò
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  60     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  593-609     Citation Subset:  IM    
Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, Italy -
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