Document Detail

Heart failure in cystic fibrosis. Treatment and prognosis of cor pulmonale with failure of the right side of the heart.
MedLine Citation:
PMID:  7361734     Owner:  NLM     Status:  MEDLINE    
Failure of the right side of the heart with cardiac dilation and fluid retention occurred in 55 of 170 patients who died of cystic fibrosis; six patients survive. All had severe hypoxia, but 24% had normal PaCO2. Cardiac catheterization showed high mean pulmonary artery pressure and resistance. Pulmonary artery wedge pressure was greater than 12 mm Hg in 40% of the patients. Mean survival was eight months. Male survival was significantly better than female survival. Digitalis treatment was of no clear benefit. Tolazoline hydrochloride was also ineffective. Recent medical advances have not substantially affected prognosis.
R C Stern; G Borkat; S S Hirschfeld; T F Boat; L W Matthews; J Liebman; C F Doershuk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  134     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Cystic Fibrosis / complications*,  mortality
Diet, Sodium-Restricted
Digitalis Glycosides / therapeutic use
Diuretics / therapeutic use
Heart Failure / etiology*,  mortality,  therapy
Pulmonary Heart Disease / etiology*,  mortality,  therapy
Tolazoline / therapeutic use
Reg. No./Substance:
0/Digitalis Glycosides; 0/Diuretics; 59-98-3/Tolazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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