Document Detail

Heart failure etiology impacts survival of patients with heart failure.
MedLine Citation:
PMID:  20193969     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: The impact of heart failure (HF) etiology on prognosis of HF is not well known.
METHODS: 3078 patients (median age 75years, 61% male) hospitalized with HF were studied. Patients were classified into six etiology groups: hypertension (HTN, 13.9%), ischemic heart disease (IHD, 42.4%), valvular disease (VHD, 9.5%), dilated cardiomyopathy (DCM, 7.9%), other (11.5%), and unknown etiology (14.8%). Patients with normal left ventricular ejection fraction (LVEF) were also included. Follow-up was up to 5years.
RESULTS: In multivariable analysis, with HTN as the reference, VHD showed the highest risk, HR 1.71 (CI: 1.3-2.2, p<0.0001), followed by DCM, HR 1.66 (CI: 1.2-2.3, p=0.002), IHD, HR 1.4 (CI: 1.1-1.7, p=0.001), and unknown etiology, HR 1.4 (CI: 1.1-1.7, p=0.007). For HF of IHD mortality risk was greater for patients with LVEF<30% (HR 2.1, CI: 1.7-2.7, p<0.0001) than for patients with LVEF≥30% (HR 1.3, CI: 1.0-1.5, p=0.03), compared to the reference (p-value for interaction<0.001).
CONCLUSION: HF due to VHD, DCM and IHD carry a worse prognosis than that of HTN. For the IHD the risk increases progressively with lower values of LVEF.
Redi Pecini; Daniel Vega Møller; Christian Torp-Pedersen; Christian Hassager; Lars Køber
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Publication Detail:
Type:  Journal Article     Date:  2010-03-02
Journal Detail:
Title:  International journal of cardiology     Volume:  149     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, University of Copenhagen, Rigshospitalet, Denmark.
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