Document Detail

Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods.
MedLine Citation:
PMID:  16709595     Owner:  NLM     Status:  MEDLINE    
AIMS: Non-potassium-sparing diuretics are commonly used in heart failure (HF). They activate the neurohormonal system, and are potentially harmful. Yet, the long-term effects of chronic diuretic use in HF are largely unknown. We retrospectively analysed the Digitalis Investigation Group (DIG) data to determine the effects of diuretics on HF outcomes.
METHODS AND RESULTS: Propensity scores for diuretic use were calculated for each of the 7788 DIG participants using a non-parsimonious multivariable logistic regression model, and were used to match 1391 (81%) no-diuretic patients with 1391 diuretic patients. Effects of diuretics on mortality and hospitalization at 40 months of median follow-up were assessed using matched Cox regression models. All-cause mortality was 21% for no-diuretic patients and 29% for diuretic patients [hazard ratio (HR) 1.31; 95% confidence interval (CI) 1.11-1.55; P = 0.002]. HF hospitalizations occurred in 18% of no-diuretic patients and 23% of diuretic patients (HR 1.37; 95% CI 1.13-1.65; P = 0.001).
CONCLUSION: Chronic diuretic use was associated with increased long-term mortality and hospitalizations in a wide spectrum of ambulatory chronic systolic and diastolic HF patients. The findings of the current study challenge the wisdom of routine chronic use of diuretics in HF patients who are asymptomatic or minimally symptomatic without fluid retention, and are on complete neurohormonal blockade. These findings, based on a non-randomized design, need to be further studied in randomized trials.
Ali Ahmed; Ahsan Husain; Thomas E Love; Giovanni Gambassi; Louis J Dell'Italia; Gary S Francis; Mihai Gheorghiade; Richard M Allman; Sreelatha Meleth; Robert C Bourge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-05-18
Journal Detail:
Title:  European heart journal     Volume:  27     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-06     Completed Date:  2007-02-28     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1431-9     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Ambulatory Care
Cardiotonic Agents / therapeutic use
Chronic Disease
Digoxin / therapeutic use
Diuretics / adverse effects*
Heart Failure / drug therapy,  mortality*
Hospitalization / statistics & numerical data*
Middle Aged
Regression Analysis
Retrospective Studies
Grant Support
1-K23-AG19211-01/AG/NIA NIH HHS; K23 AG019211/AG/NIA NIH HHS; K23 AG019211-01A2/AG/NIA NIH HHS; K23 AG019211-02/AG/NIA NIH HHS; K23 AG019211-03/AG/NIA NIH HHS; P50HL077100/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Cardiotonic Agents; 0/Diuretics; 73K4184T59/Digoxin

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