| Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods. | |
| | |
MedLine Citation:
|
PMID: 16709595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Non-potassium-sparing diuretics are commonly used in heart failure (HF). They activate the neurohormonal system, and are potentially harmful. Yet, the long-term effects of chronic diuretic use in HF are largely unknown. We retrospectively analysed the Digitalis Investigation Group (DIG) data to determine the effects of diuretics on HF outcomes. METHODS AND RESULTS: Propensity scores for diuretic use were calculated for each of the 7788 DIG participants using a non-parsimonious multivariable logistic regression model, and were used to match 1391 (81%) no-diuretic patients with 1391 diuretic patients. Effects of diuretics on mortality and hospitalization at 40 months of median follow-up were assessed using matched Cox regression models. All-cause mortality was 21% for no-diuretic patients and 29% for diuretic patients [hazard ratio (HR) 1.31; 95% confidence interval (CI) 1.11-1.55; P = 0.002]. HF hospitalizations occurred in 18% of no-diuretic patients and 23% of diuretic patients (HR 1.37; 95% CI 1.13-1.65; P = 0.001). CONCLUSION: Chronic diuretic use was associated with increased long-term mortality and hospitalizations in a wide spectrum of ambulatory chronic systolic and diastolic HF patients. The findings of the current study challenge the wisdom of routine chronic use of diuretics in HF patients who are asymptomatic or minimally symptomatic without fluid retention, and are on complete neurohormonal blockade. These findings, based on a non-randomized design, need to be further studied in randomized trials. |
| | |
Authors:
|
Ali Ahmed; Ahsan Husain; Thomas E Love; Giovanni Gambassi; Louis J Dell'Italia; Gary S Francis; Mihai Gheorghiade; Richard M Allman; Sreelatha Meleth; Robert C Bourge |
Related Documents
:
|
3744055 - Chf: reflections on current management of the older patient. 20686235 - Population pharmacokinetics of r- and s-carvedilol in japanese patients with chronic he... 16776625 - Prognostic value of homocysteinemia in patients with congestive heart failure. 17397675 - Telomere length of circulating leukocytes is decreased in patients with chronic heart f... 7081825 - Applications of choledochoduodenostomy in biliary tract obstruction. 21304025 - A comparative look at the safety profiles of intravenous iron products used in the hemo... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-05-18 |
Journal Detail:
|
Title: European heart journal Volume: 27 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-06-06 Completed Date: 2007-02-28 Revised Date: 2010-08-20 |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
|
Languages: eng Pagination: 1431-9 Citation Subset: IM |
Affiliation:
|
Department of Medicine, School of Medicine, and Department of Epidemiology, School of Public Health, and Center for Heart Failure Research, University of Alabama at Birmingham and VA Medical Center, 35294-2041, USA. aahmed@uab.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Ambulatory Care Cardiotonic Agents / therapeutic use Chronic Disease Digoxin / therapeutic use Diuretics / adverse effects* Female Heart Failure / drug therapy, mortality* Hospitalization / statistics & numerical data* Humans Male Middle Aged Prognosis Regression Analysis Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
1-K23-AG19211-01/AG/NIA NIH HHS; K23 AG019211-01A2/AG/NIA NIH HHS; K23 AG019211-02/AG/NIA NIH HHS; K23 AG019211-03/AG/NIA NIH HHS; P50HL077100/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Diuretics; 20830-75-5/Digoxin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation between apramycin and gentamicin use in pigs and an increasing reservoir of gentamicin-r...
Next Document: Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.