| Heart failure and cachexia: insights offered from molecular biology. | |
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MedLine Citation:
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PMID: 17981550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic heart failure (CHF) is an enormous medical and communal burden. The syndrome is common, carries a grim prognosis and severely impacts quality of life. Those patients who develop cardiac cachexia combat both important disability and a poor outlook. Muscle wasting is a critical component of cachexia. The pathophysiological determinants are numerous and some of them are common to other chronic severe illnesses. There is increasing awareness, however, that heart failure related myopathy is a distinct entity, characterized by specific functional, structural and morphologic changes and the involvement of several neurohormonal pathways, catabolic processes, a pro-inflammatory environment and increased oxidative stress. Although clear-cut evidence based solutions for the problem are not readily available, the modulating effects of regular exercise in CHF patients suggest that physical training should at least be incorporated in the essentially multi-disciplinary approach. |
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Authors:
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Viviane M A Conraads; Vicky Y Hoymans; Christiaan J Vrints |
Publication Detail:
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Type: Journal Article; Review Date: 2008-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 325-35 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Centre for Cell Therapy and Regenerative Medicine, University Hospital Antwerp, Belgium. Viviane.Conraads@uza.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cachexia / complications* Catecholamines / metabolism Exercise Ghrelin / metabolism Heart Failure / complications* Humans Inflammation Leptin / metabolism Muscle, Skeletal / metabolism Neurosecretory Systems Oxidative Stress Physical Conditioning, Animal |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Ghrelin; 0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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