Document Detail

Heart failure and the brain: new perspectives.
MedLine Citation:
PMID:  12529279     Owner:  NLM     Status:  MEDLINE    
Despite recent therapeutic advances, the prognosis for patients with heart failure remains dismal. Unchecked neurohumoral excitation is a critical element in the progressive clinical deterioration associated with the heart failure syndrome, and its peripheral manifestations have become the principal targets for intervention. The link between peripheral systems activated in heart failure and the central nervous system as a source of neurohumoral drive has therefore come under close scrutiny. In this context, the forebrain and particularly the paraventricular nucleus of the hypothalamus have emerged as sites that sense humoral signals generated peripherally in response to the stresses of heart failure and contribute to the altered volume regulation and augmented sympathetic drive that characterize the heart failure syndrome. This brief review summarizes recent studies from our laboratory supporting the concept that the forebrain plays a critical role in the pathogenesis of ischemia-induced heart failure and suggesting that the forebrain contribution must be considered in designing therapeutic strategies. Forebrain signaling by neuroactive products of the renin-angiotensin system and the immune system are emphasized.
Robert B Felder; Joseph Francis; Zhi-Hua Zhang; Shun-Guang Wei; Robert M Weiss; Alan Kim Johnson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  284     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-16     Completed Date:  2003-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R259-76     Citation Subset:  IM    
Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
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MeSH Terms
Brain / physiopathology*
Heart Failure / physiopathology*
Hypothalamus / physiopathology
Models, Biological
Renin-Angiotensin System
Reg. No./Substance:

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