Document Detail


Heart disease and changes in pulse wave velocity and pulse pressure amplification in the elderly over 80 years: the PARTAGE Study.
MedLine Citation:
PMID:  20634719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Pulse wave velocity (PWV) and pulse pressure amplification (PPA) are independent predictors of cardiovascular risk, mainly in the elderly. The aim of the current research was to determine the influence of PPA and PWV, both manifestations of arterial stiffness, on heart disease in the elderly.
METHODS: The study population consisted of 1042 participants (814 women) aged 80 years and over who participated in the PARTAGE study. Carotid-femoral PWV was determined in order to assess aortic stiffness. Central aortic blood pressure values and central pulse wave analysis were obtained using the calibration method applied on the common carotid artery by a PulsePen tonometer. Amplification phenomenon was expressed as PPA, that is, the percentage of increase of pulse pressure in the brachial artery relative to central pulse pressure. Heart disease was defined as presence of heart failure, ischemic heart disease or atrial fibrillation.
RESULTS: PPA was significantly lower in patients with heart disease, independently of the presence of hypertension, diabetes or both. Heart disease was present in 61.8% of participants with PPA less than 10%, in 46.2% of participants with PPA between 10 and 20% (P < 0.01), in 42.6% of participants with PPA between 20 and 30% (P < 0.005) and in 32.5% of participants with PPA more than 30% (P < 0.001). PWV, on the contrary, was not influenced by the presence of heart disease (12.3 ± 4.0 vs. 13.5 ± 4.6 m/s) but significantly increased in presence of hypertension (14.4 ± 5.0 m/s, P < 0.001) or diabetes (16.1 ± 5.1 m/s, P < 0.001).
CONCLUSION: In the very elderly, low brachial/aortic PPA is associated with higher prevalence of heart disease.
Authors:
Paolo Salvi; Michel E Safar; Carlos Labat; Claudio Borghi; Patrick Lacolley; Athanase Benetos;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2127-33     Citation Subset:  IM    
Affiliation:
Department of Geriatrics, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00901355
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Aorta / physiology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Brachial Artery / physiology*
Carotid Arteries / physiology
Cross-Sectional Studies
Elasticity / physiology
Female
Femoral Artery / physiology
France
Heart Diseases / epidemiology,  physiopathology*
Humans
Italy
Longitudinal Studies
Male
Prevalence
Regional Blood Flow / physiology*
Risk Factors
Investigator
Investigator/Affiliation:
Rachida Benelmir / ; Séverine Buatois / ; Sylvie Gautier / ; Anna Kearney-Schwartz / ; Darko Miljkovic / ; Christine Perret-Guillaume / ; Alexandra Zervoudaki / ; Davide Agnoletti / ; Sara Capelli / ; Francesca Vaienti / ; Delphine Dubail / ; Olivier Hanon / ; Francis Guillemin / ; Francesca Marino / ; Filippo Valbusa / ; Mauro Zamboni / ; Patrick Manckoundia / ; Yves Rolland / ; Olivier Toulza /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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