Document Detail


Heart development in the spotted dolphin (Stenella attenuata).
MedLine Citation:
PMID:  12845705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marine mammals show many deviations from typical mammalian characteristics due to their high degree of specialization to the aquatic environment. In Cetaceans, some of the features of limbs and dentition resemble very ancestral patterns. In some species, hearts with a clearly bifid apex (a feature normally present during mammalian embryogenesis prior to completion of ventricular septation) have been described. However, there is a scant amount of data regarding heart development in Cetaceans, and it is not clear whether the bifid apex is the rule or the exception. We examined samples from a unique collection of embryonic dolphin specimens macroscopically and histologically to learn more about normal cardiac development in the spotted dolphin. It was found that during the dolphin's 280 days of gestation, the heart completes septation at about 35 days. However, substantial trabecular compaction, which normally occurs in chicks, mice, and humans at around that time period, was delayed until day 60, when coronary circulation became established. At that time, the apex still appeared bifid, similarly to early fetal mouse or rat hearts. By day 80, however, the heart gained a compacted, characteristic shape, with a single apex. It thus appears that the bifid apex in the adult Cetacean heart is probably particular to certain species, and its significance remains unclear.
Authors:
David Sedmera; Ivan Misek; Milan Klima; Robert P Thompson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  273     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-07     Completed Date:  2004-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-99     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. sedmera@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology*
Chick Embryo
Coronary Vessels / embryology,  physiology
Dolphins / embryology*,  physiology
Female
Heart / embryology*,  physiology
Heart Septum / embryology
Heart Ventricles / embryology
Humans
Mice
Myocardium / cytology
Rats
Ventricular Function
Grant Support
ID/Acronym/Agency:
HL50582/HL/NHLBI NIH HHS; RR16434/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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