Document Detail

Heart conduction disturbance: an HLA-B27 associated disease.
MedLine Citation:
PMID:  2059077     Owner:  NLM     Status:  MEDLINE    
In recent studies from Sweden an increased prevalence of HLA-B27 associated diseases and of HLA-B27 was found in an unselected group of men with permanently implanted pacemakers and with a heart block. Furthermore, a significantly increased prevalence of HLA-B27 was found in men with a pacemaker who had no clinical or radiological signs of HLA-B27 associated disease. To obtain more insight into the association between HLA-B27 and heart block, and the possible role of HLA-B27 in causing this block, a study was made of 35 patients with a pacemaker and heart block of unknown cause, selected from a total group of 350 men with pacemakers who were still alive at the time of the study. One of these 35 men had ankylosing spondylitis and two patients had an asymptomatic sacroiliitis, but all three were HLA-B27 negative. HLA-B27 was present in five (14%) patients, which is a significantly higher prevalence than in healthy controls (17/292, 6%). This percentage is equal to the percentage of HLA-B27 positivity found in the Swedish study on unselected men with an implanted pacemaker, in whom the presence of an HLA-B27 associated disease had been excluded. It suggests that factors other than HLA-B27 are important in the pathogenesis of heart block in most patients.
A J Peeters; S ten Wolde; M I Sedney; R R de Vries; B A Dijkmans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  50     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-08-01     Completed Date:  1991-08-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  348-50     Citation Subset:  IM    
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
HLA-B27 Antigen / analysis*
Heart Block / etiology,  immunology*,  therapy
Inflammation / immunology
Pacemaker, Artificial
Spondylitis / complications,  immunology
Spondylitis, Ankylosing / complications,  immunology
Reg. No./Substance:
0/HLA-B27 Antigen

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