| Heart block following propofol in a child. | |
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MedLine Citation:
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PMID: 10411774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present the case of a nine-year-old boy afflicted with Ondine's curse, who developed complete atrioventricular heart block after a single bolus of propofol for induction of anaesthesia for strabismus surgery. Ondine's curse, the other name for congenital central hypoventilation syndrome, is characterized by a generalized disorder of autonomic function. Propofol has no effect on the normal atrioventricular conduction system in humans but it reduces sympathetic activity and can highly potentiate other vagal stimulation factors. Heart block has been documented after propofol bolus use in adults but, to our knowledge, not in children. It would appear that propofol is not a good choice for anaesthesia in congenital central hypoventilation syndrome. |
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Authors:
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C Sochala; D Deenen; A Ville; M J Govaerts |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 9 ISSN: 1155-5645 ISO Abbreviation: Paediatr Anaesth Publication Date: 1999 |
Date Detail:
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Created Date: 1999-08-11 Completed Date: 1999-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: FRANCE |
Other Details:
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Languages: eng Pagination: 349-51 Citation Subset: IM |
Affiliation:
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Clinic of Paediatric Anaesthesia, University Children's Hospital, Queen Fabiola, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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administration & dosage Anesthetics, Intravenous / adverse effects* Atrioventricular Node / drug effects Blood Pressure / drug effects Child Electrocardiography / drug effects Heart Block / chemically induced* Heart Rate / drug effects Humans Isoflurane / administration & dosage Male Nitrous Oxide / administration & dosage Oxygen / administration & dosage Propofol / adverse effects* Sleep Apnea Syndromes / complications, physiopathology Strabismus / complications, surgery Sympathetic Nervous System / drug effects Vagus Nerve / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 10024-97-2/Nitrous Oxide; 2078-54-8/Propofol; 26675-46-7/Isoflurane; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Paediatr Anaesth. 2000;10(2):226
[PMID:
10787270
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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