Document Detail

Heart activity and autistic behavior in infants and toddlers with fragile X syndrome.
MedLine Citation:
PMID:  22515825     Owner:  NLM     Status:  MEDLINE    
The present study contrasted physiological arousal in infants and toddlers with fragile X syndrome to typically developing control participants and examined physiological predictors early in development to autism severity later in development in fragile X syndrome. Thirty-one males with fragile X syndrome (ages 8-40 months) and 25 age-matched control participants were included. The group with fragile X syndrome showed shorter interbeat intervals (IBIs), lower vagal tone (VT), and less modulation of IBI. Data suggested a nonlinear effect with IBI and autistic behavior; however, a linear effect with VT and autistic behavior emerged. These findings suggest that atypical physiological arousal emerges within the first year and predicts severity of autistic behavior in fragile X syndrome. These relationships are complex and dynamic, likely reflecting endogenous factors assumed to reflect atypical brain function secondary to reduced fragile X mental retardation protein. This research has important implications for the early identification and treatment of autistic behaviors in young children with fragile X syndrome.
Jane E Roberts; Bridgette Tonnsen; Ashley Robinson; Svetlana V Shinkareva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal on intellectual and developmental disabilities     Volume:  117     ISSN:  1944-7515     ISO Abbreviation:  Am J Intellect Dev Disabil     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-20     Completed Date:  2012-06-15     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  101492916     Medline TA:  Am J Intellect Dev Disabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-102     Citation Subset:  IM    
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MeSH Terms
Autistic Disorder / etiology,  physiopathology*
Child Development / physiology
Child, Preschool
Cross-Sectional Studies
Fragile X Syndrome / complications,  physiopathology*
Heart / innervation,  physiology*
Heart Rate / physiology
Infant Behavior / physiology
Severity of Illness Index
Vagus Nerve / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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