| Heart activity and autistic behavior in infants and toddlers with fragile x syndrome. | |
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MedLine Citation:
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PMID: 22515825 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract The present study contrasted physiological arousal in infants and toddlers with fragile X syndrome to typically developing control participants and examined physiological predictors early in development to autism severity later in development in fragile X syndrome. Thirty-one males with fragile X syndrome (ages 8-40 months) and 25 age-matched control participants were included. The group with fragile X syndrome showed shorter interbeat intervals (IBIs), lower vagal tone (VT), and less modulation of IBI. Data suggested a nonlinear effect with IBI and autistic behavior; however, a linear effect with VT and autistic behavior emerged. These findings suggest that atypical physiological arousal emerges within the first year and predicts severity of autistic behavior in fragile X syndrome. These relationships are complex and dynamic, likely reflecting endogenous factors assumed to reflect atypical brain function secondary to reduced fragile X mental retardation protein. This research has important implications for the early identification and treatment of autistic behaviors in young children with fragile X syndrome. |
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Authors:
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Jane E Roberts; Bridgette Tonnsen; Ashley Robinson; Svetlana V Shinkareva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal on intellectual and developmental disabilities Volume: 117 ISSN: 1944-7515 ISO Abbreviation: Am J Intellect Dev Disabil Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-04-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101492916 Medline TA: Am J Intellect Dev Disabil Country: United States |
Other Details:
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Languages: eng Pagination: 90-102 Citation Subset: IM |
Affiliation:
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University of South Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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