Document Detail

Heart rate and heart failure. Not a simple relationship.
MedLine Citation:
PMID:  21041970     Owner:  NLM     Status:  MEDLINE    
Resting heart rate (HR) is increased in patients with heart failure (HF). Sustained tachycardia can cause HF. The magnitude of HR reduction in treatment trials of patients with HF is associated with a reduction in mortality. Yet, the mechanistic and causal role of HR in HF is unclear, and recent trials with selective HR reduction have not consistently achieved benefit: the BEAUTIFUL trial in patients with coronary artery disease and left ventricular dysfunction did not achieve a significant benefit in the primary endpoint, and only the coronary outcome, not the HF outcome, was improved; in the SHIFT trial, however, patients with symptomatic heart failure had a significant benefit in the primary endpoint of cardiovascular mortality and hospitalization for worsening HF. The present review addresses the pathophysiology of tachycardia-induced HF, the force-frequency relationship, and the clinical potential of HR reduction in HF.
Gerd Heusch
Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-05-23     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany.
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MeSH Terms
Benzazepines / pharmacology,  therapeutic use
Cardiac Pacing, Artificial / adverse effects
Coronary Artery Disease / physiopathology
Disease Models, Animal
Heart Failure / drug therapy,  etiology,  physiopathology*,  prevention & control
Heart Rate* / drug effects
Models, Cardiovascular
Multicenter Studies as Topic
Myocardial Ischemia / physiopathology
Myocardium / pathology
Randomized Controlled Trials as Topic
Stress, Mechanical
Tachycardia / complications,  drug therapy,  physiopathology*
Tachycardia, Supraventricular / drug therapy,  physiopathology
Treatment Outcome
Ventricular Dysfunction, Left / etiology,  physiopathology,  prevention & control
Reg. No./Substance:
0/Benzazepines; 155974-00-8/ivabradine

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