Document Detail

Heart Fields and Cardiac Morphogenesis.
MedLine Citation:
PMID:  25274757     Owner:  NLM     Status:  Publisher    
In this review, we focus on two important steps in the formation of the embryonic heart: (i) the progressive addition of late differentiating progenitor cells from the second heart field that drives heart tube extension during looping morphogenesis, and (ii) the emergence of patterned proliferation within the embryonic myocardium that generates distinct cardiac chambers. During the transition between these steps, the major site of proliferation switches from progenitor cells outside the early heart to proliferation within the embryonic myocardium. The second heart field and ballooning morphogenesis concepts have major repercussions on our understanding of human heart development and disease. In particular, they provide a framework to dissect the origin of congenital heart defects and the regulation of myocardial proliferation and differentiation of relevance for cardiac repair.
Robert G Kelly; Margaret E Buckingham; Antoon F Moorman
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Publication Detail:
Type:  REVIEW     Date:  2014-10-1
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  4     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-2     Completed Date:  -     Revised Date:  2014-10-3    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.
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