Document Detail


Heart Failure with Preserved Ejection Fraction: Persistent Diagnosis, Therapeutic Enigma.
MedLine Citation:
PMID:  22081782     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart failure with preserved ejection fraction (HFPEF) is increasing in prevalence with the aging of the population, and morbidity and mortality rates are comparable to that of heart failure with reduced ejection fraction (HFREF). The diagnosis can be difficult to make, especially in older adults, stemming from the presence of multiple comorbid illnesses with confounding symptoms. New diagnostic tools have resulted in guidelines proposed to define and diagnose HFPEF. Recent literature focusing on the pathophysiology underlying this disease suggests multiple mechanisms are involved in the generation of the phenotype, such as abnormal relaxation and ventricular-vascular coupling, chronotropic incompetence, volume overload, and redistribution and /or endothelial dysfunction. Currently, no clinically proven treatments are shown to decrease morbidity and mortality in this population; however, there may be a novel multidisciplinary and multistage treatment strategy that can be studied to address this complex disease which incorporates pharmacologic and non-pharmacologic therapeutics.
Authors:
Taslima Bhuiyan; Mathew S Maurer
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current cardiovascular risk reports     Volume:  5     ISSN:  1932-9563     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101463024     Medline TA:  Curr Cardiovasc Risk Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  440-449     Citation Subset:  -    
Affiliation:
Division of Cardiology, Columbia University Medical Center, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
K24 AG036778-02//NIA NIH HHS; R01 AG027518-04//NIA NIH HHS

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