Document Detail

Hearing results following intratympanic gentamicin perfusion for Ménière's disease.
MedLine Citation:
PMID:  18954493     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate hearing results following intratympanic gentamicin perfusion in patients with Ménière's disease. MATERIALS AND METHODS: Middle-ear perfusion of 0.4 ml of gentamicin 40 mg/ml solution was performed in Ménière's disease patients who had previously failed to respond to other medical treatment. RESULTS: Between May 1999 and November 2005, 22 patients (mean age 58.5 years) underwent intratympanic gentamicin perfusion. Mean follow up was 30 months. At the first post-perfusion visit (four to six weeks following perfusion), three of the 22 patients (13.63 per cent) had a pure tone average improvement of at least 10 dB, 15 (68.18 per cent) showed no change and four (18.18 per cent) demonstrated a decrease in hearing of more than 10 dB. Regarding speech discrimination scores, one patient (4.54 per cent) exhibited an improvement of at least 15 per cent, 15 (68.18 per cent) showed no change and six (27.27 per cent) showed a decrease of at least 15 per cent. After long-term follow up (12-40 months following perfusion), 10 patients (45.45 per cent) showed stable hearing, and 12 (54.54 per cent) exhibited a pure tone average decrease of more than 10 dB. Six patients (27.27 per cent) showed a speech discrimination score decrease of at least 15 per cent, while 16 (72.72 per cent) had no change. Complete cessation of vertigo was reported by 20 of the 22 patients (90.9 per cent), while two (9.09 per cent) reported episodic vertigo spells. CONCLUSION: Intratympanic gentamicin perfusion provides effective control of vertigo in patients with Ménière's disease. However, significant hearing loss may occur immediately after perfusion; therefore, this treatment should be considered only for patients whose hearing has already been affected by the disease.
E Kyrodimos; I Aidonis; A Sismanis
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Publication Detail:
Type:  Journal Article     Date:  2008-10-28
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  123     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  AIM; IM    
Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage*
Audiometry, Pure-Tone
Gentamicins / administration & dosage*
Hearing Loss, Sensorineural / epidemiology*,  etiology
Meniere Disease / complications,  drug therapy*
Middle Aged
Retrospective Studies
Speech Perception / physiology
Tympanic Membrane
Vertigo / epidemiology,  etiology
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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