Document Detail


Hearing molecules, mechanism and transportation: Modeled in Drosophila melanogaster.
MedLine Citation:
PMID:  25081222     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mechanosensory transduction underlies the perception of touch, sound and acceleration. The mechanical signals exist in the environment are re-sensed by the specialized mechanosensory cells, which convert the external forces into the electrical signals. Hearing is a magnificent example that relies on the mechanotransduction mediated by the auditory cells, for example the inner-ear hair cells in vertebrates and the Johnston's organ in fly. Previous studies have shown the fundamental physiological processes in the fly and vertebrate auditory organs are similar, suggesting that there might be a set of similar molecules underlying these processes. The molecular studies of the fly Johnston's organ have been shown to be remarkably successful in discovering the developmental and functional genes that provided further implications in vertebrates. Several evolutionarily conserved molecules and signaling pathways have been shown to govern the development of the auditory organs in both vertebrates and invertebrates. The current review describes the similarities and differences between the vertebrate and fly auditory organs at developmental, structural, molecular and transportation levels. © 2014 Wiley Periodicals, Inc. Develop Neurobiol, 2014.
Authors:
Naveen Prakash Bokolia; Monalisa Mishra
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-1
Journal Detail:
Title:  Developmental neurobiology     Volume:  -     ISSN:  1932-846X     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., a Wiley company.
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