Document Detail


Hearing loss and cognitive decline in older adults.
MedLine Citation:
PMID:  23337978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, ≥80) who underwent audiometric testing in year 5. Participants were followed up for 6 years. Hearing was defined at baseline using a pure-tone average of thresholds at 0.5 to 4 kHz in the better-hearing ear. Cognitive testing was performed in years 5, 8, 10, and 11 and consisted of the 3MS (measuring global function) and the Digit Symbol Substitution test (measuring executive function). Incident cognitive impairment was defined as a 3MS score of less than 80 or a decline in 3MS score of more than 5 points from baseline. Mixed-effects regression and Cox proportional hazards regression models were adjusted for demographic and cardiovascular risk factors. RESULTS In total, 1162 individuals with baseline hearing loss (pure-tone average >25 dB) had annual rates of decline in 3MS and Digit Symbol Substitution test scores that were 41% and 32% greater, respectively, than those among individuals with normal hearing. On the 3MS, the annual score changes were -0.65 (95% CI, -0.73 to -0.56) vs -0.46 (95% CI, -0.55 to -0.36) points per year (P = .004). On the Digit Symbol Substitution test, the annual score changes were -0.83 (95% CI, -0.94 to -0.73) vs -0.63 (95% CI, -0.75 to -0.51) points per year (P = .02). Compared to those with normal hearing, individuals with hearing loss at baseline had a 24% (hazard ratio, 1.24; 95% CI, 1.05-1.48) increased risk for incident cognitive impairment. Rates of cognitive decline and the risk for incident cognitive impairment were linearly associated with the severity of an individual's baseline hearing loss. CONCLUSIONS Hearing loss is independently associated with accelerated cognitive decline and incident cognitive impairment in community-dwelling older adults. Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline.
Authors:
Frank R Lin; Kristine Yaffe; Jin Xia; Qian-Li Xue; Tamara B Harris; Elizabeth Purchase-Helzner; Suzanne Satterfield; Hilsa N Ayonayon; Luigi Ferrucci; Eleanor M Simonsick;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA internal medicine     Volume:  173     ISSN:  2168-6114     ISO Abbreviation:  JAMA Intern Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-04-16     Revised Date:  2014-04-25    
Medline Journal Info:
Nlm Unique ID:  101589534     Medline TA:  JAMA Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / physiology*,  psychology
Audiometry
Cognition Disorders / diagnosis,  etiology*
Female
Hearing Loss / complications*,  diagnosis
Humans
Incidence
Linear Models
Male
Neuropsychological Tests
Proportional Hazards Models
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
K23 DC011279/DC/NIDCD NIH HHS; K23DC011279/DC/NIDCD NIH HHS; N01-AG62101/AG/NIA NIH HHS; N01-AG62103/AG/NIA NIH HHS; N01-AG62106/AG/NIA NIH HHS; P30-AG02133/AG/NIA NIH HHS; R01-AG028050/AG/NIA NIH HHS; R01-NR012459/NR/NINR NIH HHS
Investigator
Investigator/Affiliation:
Anne B Newman / ; Diane Ives / ; Suzanne Satterfield / ; Jan Elam / ; Steven R Cummings / ; Michael C Nevitt / ; Susan M Rubin / ; Tamara B Harris / ; Melissa E Garcia /
Comments/Corrections
Comment In:
JAMA Intern Med. 2013 Feb 25;173(4):299   [PMID:  23338615 ]
Evid Based Nurs. 2014 Apr;17(2):60-1   [PMID:  23842726 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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