Document Detail


Healthy aging: is smaller better? - a mini-review.
MedLine Citation:
PMID:  22261798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent report of virtually complete protection from diabetes and cancer in a population of people with hereditary dwarfism revived interest in elucidating the relationships between growth, adult body size, age-related disease and longevity. In many species, smaller individuals outlive those that are larger and a similar relationship was shown in studies of various human populations. Adult body size is strongly dependent on the actions of growth hormone (GH) and the absence of GH or GH receptor in mice leads to a remarkable extension of longevity. Many mechanisms that may account for, or contribute to, this association have been identified. It is suggested that modest modifications of the diet at different ages may extend human healthspan and lifespan by reducing levels of hormones that stimulate growth.
Authors:
Andrzej Bartke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-18
Journal Detail:
Title:  Gerontology     Volume:  58     ISSN:  1423-0003     ISO Abbreviation:  Gerontology     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-28     Completed Date:  2012-11-05     Revised Date:  2014-01-29    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  337-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiopathology
Aging / pathology*,  physiology*
Animals
Body Size / physiology*
Dwarfism / pathology,  physiopathology
Growth Hormone / deficiency,  physiology
Humans
Insulin / deficiency,  physiology
Insulin-Like Growth Factor I / deficiency,  physiology
Longevity / physiology*
Mice
Models, Animal
Receptors, Somatotropin / deficiency,  physiology
Signal Transduction
TOR Serine-Threonine Kinases / deficiency,  physiology
Grant Support
ID/Acronym/Agency:
P01 AG031736/AG/NIA NIH HHS; P01 AG031736/AG/NIA NIH HHS; R01 AG019899/AG/NIA NIH HHS; R01AGO19899//PHS HHS; R21 AG038850/AG/NIA NIH HHS; R21 AG038850/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; 0/Receptors, Somatotropin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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