Document Detail

Healthcare resource utilization and costs associated with recurrent episodes of atrial fibrillation: the FRACTAL registry.
MedLine Citation:
PMID:  17451468     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Drivers of cost in the atrial fibrillation (AF) population are not fully understood. We sought to characterize the resource utilization and costs of treating new-onset AF, with emphasis on the incremental costs associated with recurrent episodes of AF over time.
METHODS AND RESULTS: An inception cohort of 973 AF patients was followed at 3-6 month intervals in an observational registry over a mean of 24 +/- 9 months. AF therapies, clinical outcomes, and both inpatient and outpatient medical resource utilization were tracked at each follow-up interval. Registry patients were managed primarily with cardioversion and pharmacological therapy. Direct healthcare costs were calculated from a U.S. perspective by multiplying measures of resource utilization by representative price weights. Costs were compared among patients in whom the initial episode of AF became permanent and patients who initially achieved sinus rhythm and had either 0, 1-2, or > or = 3 documented recurrences during follow-up. Mean annual costs for these four groups were $2,372, $3,385, $6,331, and $10,312 per patient per year, respectively (P < 0.001 for trend), with the largest variation related to hospital costs. In multivariable analysis controlling for demographic characteristics and baseline cardiac and comorbid conditions, each documented recurrence of AF was found to increase annual healthcare costs by approximately $1,600.
CONCLUSION: Following initial diagnosis, patients with AF treated with traditional therapies incur $4,000-$5,000 in annual direct healthcare costs. Costs are markedly higher in patients with multiple AF recurrences. These data may be helpful in evaluating the economic impact of new technologies for treating AF.
Matthew R Reynolds; Vidal Essebag; Peter Zimetbaum; David J Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-19
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  18     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-24     Completed Date:  2007-08-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  628-33     Citation Subset:  IM    
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MeSH Terms
Ambulatory Care / economics,  statistics & numerical data
Atrial Fibrillation / economics*,  epidemiology,  therapy
Canada / epidemiology
Cohort Studies
Drug Therapy / economics,  statistics & numerical data
Follow-Up Studies
Health Care Costs / statistics & numerical data*
Health Care Surveys
Health Resources / utilization*
Hospitalization / economics,  statistics & numerical data
Multivariate Analysis
Regression Analysis
United States / epidemiology
Grant Support
Comment In:
J Cardiovasc Electrophysiol. 2007 Jun;18(6):634-5   [PMID:  17472712 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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