| Health-related quality of life of youth with inflammatory bowel disease: a comparison with published data using the PedsQL 4.0 generic core scales. | |
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MedLine Citation:
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PMID: 19998462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study compared youth and parent-proxy reports of health-related quality of life (HRQoL) among youth with inflammatory bowel disease (IBD) to published comparison group data and examined concordance between youth and parent-proxy reports of HRQoL. METHODS: One hundred thirty-six youth and parent-proxy reports on the PedsQL 4.0 Generic Core Scales were compared to published data from chronically ill, acutely ill, and healthy comparison groups using independent samples t-tests. Reporter agreement was examined using paired samples t-tests and intraclass correlations (ICCs). RESULTS: Youth with IBD reported lower psychosocial functioning than the healthy comparison group, higher physical and social functioning than the chronically ill group, and lower school functioning than all published comparison groups. Parent-proxy reports of youth HRQoL were higher than the chronically ill group, but lower than the healthy group on all scales except psychosocial functioning. Youth with active IBD reported lower physical health domain scores than youth with inactive disease. Concordance between youth and parent-proxy reports was moderate, with the lowest agreement in school and social functioning. CONCLUSIONS: Youth with IBD and their parents rate HRQoL as lower than healthy youth but do not perceive the impact of IBD to be as limiting as in other chronic conditions. Youth report suggests that IBD may be particularly detrimental to HRQoL in the school functioning domain. Moderate agreement between parent and youth reports substantiates continued use of multiple informants in studies of pediatric HRQoL. |
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Authors:
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Jennifer Hauser Kunz; Kevin A Hommel; Rachel Neff Greenley |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inflammatory bowel diseases Volume: 16 ISSN: 1536-4844 ISO Abbreviation: Inflamm. Bowel Dis. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-08-20 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9508162 Medline TA: Inflamm Bowel Dis Country: United States |
Other Details:
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Languages: eng Pagination: 939-46 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. JHauser@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Mercaptopurine
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analogs & derivatives,
therapeutic use Adolescent Adult Child Female Humans Inflammatory Bowel Diseases / drug therapy, psychology* Interpersonal Relations* Male Mesalamine / therapeutic use Methylthioinosine / therapeutic use Middle Aged Parents / psychology Quality of Life / psychology* Self Concept* Severity of Illness Index Sickness Impact Profile* Social Adjustment* Thioguanine / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK079037/DK/NIDDK NIH HHS; K23 DK079037-04/DK/NIDDK NIH HHS; M01 RR 08084/RR/NCRR NIH HHS; P30 DK078392/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/azathiopurine; 154-42-7/Thioguanine; 342-69-8/Methylthioinosine; 50-44-2/6-Mercaptopurine; 89-57-6/Mesalamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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