| Health-related quality of life in patients with primary Sj?gren's syndrome: relationship with serum levels of proinflammatory cytokines. | |
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MedLine Citation:
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PMID: 19575332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A cross-sectional study of 30 patients with primary Sj?gren's syndrome (pSS) was performed to analyse the health-related quality of life and its relationship with serum levels of macrophage- and lymphocyte-derived cytokines. PATIENTS AND METHODS: Health-related quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Serum levels of interleukin (IL)-1beta, IL-6, IL-10, tumour necrosis factor (TNF)-alpha, and gamma-interferon (gamma-INF) were analysed by a sandwich immunoassay-based protein array system. RESULTS: Each of the eight scales of the SF-36 evaluating quality of life, as well as the physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS patients. Similarly, patients with pSS showed significantly increased concentrations of each of the five cytokines analysed, when compared with the healthy control group (n = 20). In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. Those patients with concentrations of IL-6 higher than those of the healthy controls showed a significantly lower score in the dimensions of bodily pain and physical functioning, and in the PCS. CONCLUSIONS: Patients with pSS showed increased levels of several macrophage- and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals. |
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Authors:
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R Baturone; M J Soto; M M?rquez; I Mac?as; M Montes de Oca; F Medina; N Chozas; S Garc?a-P?rez; J A Gir?n-Gonz?lez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of rheumatology Volume: 38 ISSN: 1502-7732 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: England |
Other Details:
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Languages: eng Pagination: 386-9 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Puerta del Mar University Hospital, C?diz, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cytokines / blood* Female Health Status* Health Surveys Humans Immunoassay Interferon-gamma / blood Interleukin-10 / blood Interleukin-1beta / blood Interleukin-6 / blood Male Middle Aged Quality of Life* Questionnaires Sjogren's Syndrome / blood* Statistics, Nonparametric Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma |
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