Document Detail


Health-related quality of life in patients with primary Sj?gren's syndrome: relationship with serum levels of proinflammatory cytokines.
MedLine Citation:
PMID:  19575332     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A cross-sectional study of 30 patients with primary Sj?gren's syndrome (pSS) was performed to analyse the health-related quality of life and its relationship with serum levels of macrophage- and lymphocyte-derived cytokines. PATIENTS AND METHODS: Health-related quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Serum levels of interleukin (IL)-1beta, IL-6, IL-10, tumour necrosis factor (TNF)-alpha, and gamma-interferon (gamma-INF) were analysed by a sandwich immunoassay-based protein array system. RESULTS: Each of the eight scales of the SF-36 evaluating quality of life, as well as the physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS patients. Similarly, patients with pSS showed significantly increased concentrations of each of the five cytokines analysed, when compared with the healthy control group (n = 20). In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. Those patients with concentrations of IL-6 higher than those of the healthy controls showed a significantly lower score in the dimensions of bodily pain and physical functioning, and in the PCS. CONCLUSIONS: Patients with pSS showed increased levels of several macrophage- and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals.
Authors:
R Baturone; M J Soto; M M?rquez; I Mac?as; M Montes de Oca; F Medina; N Chozas; S Garc?a-P?rez; J A Gir?n-Gonz?lez
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  38     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  386-9     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Puerta del Mar University Hospital, C?diz, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cytokines / blood*
Female
Health Status*
Health Surveys
Humans
Immunoassay
Interferon-gamma / blood
Interleukin-10 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Male
Middle Aged
Quality of Life*
Questionnaires
Sjogren's Syndrome / blood*
Statistics, Nonparametric
Tumor Necrosis Factor-alpha / blood
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

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