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Health related quality of life and disease-specific complaints among multiple myeloma patients up to 10 years after diagnosis: results from a population-based study using the PROFILES registry.
MedLine Citation:
PMID:  22762785     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: This prospective population-based study describes health related quality of life (HRQOL) and disease-specific complaints of multiple myeloma (MM) patients up to 10 years post-diagnosis. METHODS: The Eindhoven Cancer Registry was used to select all patients diagnosed with MM from 1999 to 2010. MM patients completed the EORTC QLQ-C30 and EORTC QLQ-MY20 questionnaires at baseline (n=156; 74% response rate) and one year later (n=80). The EORTC QLQ-C30 was also completed by an age- and sex-matched normative population (n=500). RESULTS: MM patients reported statistically significant and clinically relevant worse scores on all EORTC QLQ-C30 scales (all p's at least <0.01) compared to the norm. Also, MM patients reported a mean decrease (e.g. worsening) between baseline and 1-year follow-up scores for: quality of life (mean 68 vs. 55 respectively, p<0.001; 74% of patients had a deteriorated score), fatigue (33 vs. 39, p<0.05; 50%), nausea and vomiting (6.3 vs. 13, p<0.05; 71%), pain (33 vs. 43, p<0.05; 59%) and dyspnea (17 vs. 33, p<0.001; 66%). The most bothering symptoms during the past week were; tingling hands/feet (32%), back pain (28%), bone aches/pain (26%), pain in arm/shoulder (19%), and feeling drowsy (18%). Also, 37% worried about their future health, 34% thought about their disease, and 21% worried about dying. CONCLUSION: MM patients experience a very high symptom burden and low HRQOL. Future studies should focus on possible mechanisms that can predict low HRQOL and high symptom burden in MM patients, and should investigate optimal ways to alleviate these. © 2012 John Wiley & Sons A/S.
Authors:
Floortje Mols; Simone Oerlemans; Allert H Vos; Ad Koster; Silvia Verelst; Pieter Sonneveld; Lonneke V van de Poll-Franse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-4
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
CoRPS - Center of Research on Psychology in Somatic diseases, Department of Medical Psychology, Tilburg University, The Netherlands; Comprehensive Cancer Centre South (CCCS), Eindhoven Cancer Registry, Eindhoven, The Netherlands.
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