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Health outcomes of children fathered by patients treated with radioiodine for thyroid cancer.
MedLine Citation:
PMID:  19250267     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Context and objectives  Radiation is known to be mutagenic. The present study analyses birth outcomes and the health of offspring from men previously exposed to (131) I treatment for thyroid carcinoma. Methods  Data on 493 pregnancies (356 from 173 untreated fathers, 23 from 17 patients who have undergone surgery alone and 114 from 63 fathers who received (131) I) were obtained by interviewing male patients treated for thyroid carcinoma who had not received significant external radiation to the testes. Among these pregnancies, 73 were conceived from fathers who had received more than 370 MBq. Results  The mean activity for the 114 pregnancies fathered by 63 patients was 3993 MBq leading to an estimated radiation dose of 9·2 cGy to the testes (MIRD committee coefficient). No significant differences between untreated and treated fathers were found for any adverse outcome. Conclusion  There was no evidence that exposure to radioiodine affects the outcome of subsequent pregnancies and offspring, whatever the event considered. As our study is underpowered, the question of whether testicular irradiation, fractionated or not, is linked to impaired fertility or consequences on offspring remains to be established.
Authors:
Jérôme-Philippe Garsi; Martin Schlumberger; Marcel Ricard; Martine Labbé; Claudia Ceccarelli; Claire Schvartz; Michel Henry-Amar; Stéphane Bardet; Carole Rubino; Florent De Vathaire
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Publication Detail:
Type:  Journal Article     Date:  2009-02-25
Journal Detail:
Title:  Clinical endocrinology     Volume:  71     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2011-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  880-3     Citation Subset:  IM    
Copyright Information:
© 2009 Blackwell Publishing Ltd.
Affiliation:
Inserm U605 Institut Gustave Roussy Université Paris XI, Villejuif, France University of Pisa, Pisa, Italy Institut Jean Godinot, Reims Centre François Baclesse, Caen, France.
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