Document Detail

Health implications of milk containing beta-casein with the A2 genetic variant.
MedLine Citation:
PMID:  16403684     Owner:  NLM     Status:  MEDLINE    
Milk from dairy cows has long provided a high quality source of protein and selected micronutrients such as calcium to most populations. Recently, a relationship between disease risk and consumption of a specific bovine ss-casein fraction either A1 or A2 genetic variants has been identified. Populations, which consume milk containing high levels of ss-casein A2 variant, have a lower incidence of cardiovascular disease and type 1 diabetes. Furthermore, consumption of milk with the A2 variant may be associated with less severe symptoms of autism and schizophrenia. The mechanism of action focuses on ss-casein A1 and related forms preferentially that are able to produce a bioactive opioid peptide, ss-casomorphin-7 (ss-CM-7) during digestion. Infants may absorb ss-CM-7 due to an immature gastrointestinal tract. Adults, on the other hand, appear to reap the biological activity locally on the intestinal brush boarder. ss-CM-7 can potentially affect numerous opioid receptors in the nervous, endocrine, and immune systems. Whether there is a definite health benefit to milk containing the A2 genetic variant is unknown and requires further investigation.
Stacey J Bell; Gregory T Grochoski; Andrew J Clarke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in food science and nutrition     Volume:  46     ISSN:  1040-8398     ISO Abbreviation:  Crit Rev Food Sci Nutr     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-11     Completed Date:  2006-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8914818     Medline TA:  Crit Rev Food Sci Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Research and Development, Ideasphere, Inc., 56 Amherst Road, Belmont, MA, 02478, USA.
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MeSH Terms
Cardiovascular Diseases / epidemiology*
Caseins / adverse effects*,  genetics*
Diabetes Mellitus, Type 1 / epidemiology*
Genetic Variation / genetics*
Milk / adverse effects*
Risk Factors
Reg. No./Substance:

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