| Health and growth of infants breastfed by Norplant contraceptive implants users: a six-year follow-up study. | |
| | |
MedLine Citation:
|
PMID: 12169382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective of the study was to evaluate safety to infants whose mothers used Norplant levonorgestrel implants during breastfeeding. A nonrandomized clinical trial design was used. Participants were 220 and 222 healthy breastfed infants of mothers initiating use of Norplant or T-Cu IUD, respectively, at 55 days to 60 days postpartum. Infants were followed from birth through age 6 years. Breastfeeding pattern, infant growth, and disease events were recorded monthly in the first year, three-monthly in the second, and annually thereafter. Most mothers continued use of Norplant (96.4%) and T-Cu (94.1%) during lactation, and 2140 months of infant exposure to levonorgestrel were accumulated. Breastfeeding pattern and infants growth, from admission through age 6 years, were similar in both groups. In the first year, breastfed infants in the Norplant group had higher incidence rates (p < 0.05) of mild episodes of respiratory infections (adjusted RR 1.17, CI 1.08-1.27), skin conditions (adjusted RR 1.46, CI 1.20-1.79), and eye infections (unadjusted RR 1.49, CI 1.03-2.18) than the control group. Later on, a higher proportion of infants in the T-Cu group showed neurological conditions. Although breastfeeding patterns and infant growth is not affected by Norplant use during lactation, the effect on infants' health of steroidal contraception should be further evaluated. |
| | |
Authors:
|
Verónica Schiappacasse; Soledad Díaz; Ana Zepeda; Reynaldo Alvarado; Carmen Herreros |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Contraception Volume: 66 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-08-09 Completed Date: 2002-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
|
Languages: eng Pagination: 57-65 Citation Subset: IM |
Affiliation:
|
Instituto Chileno de Medicina Reproductiva, Consultorio de Planificación Familiar, J.V. Lastarria 29, Depto. 101, Santiago, Chile. icmer@icmer.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Breast Feeding* Child Child Development* Child, Preschool Contraceptive Agents, Female / adverse effects*, blood Drug Implants Eye Diseases / etiology Female Humans Incidence Infant Infant, Newborn Levonorgestrel / administration & dosage, adverse effects*, blood Male Prospective Studies Respiratory Tract Infections / etiology Skin Diseases / etiology |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptive Agents, Female; 0/Drug Implants; 797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of interaction potential of certain concurrently administered drugs with pharmacological ...
Next Document: Oral contraceptive use and exercise-induced muscle damage and recovery.