Document Detail


Health effects of ambient particulate matter--biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures.
MedLine Citation:
PMID:  18300050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle properties such as surface area and oxidative potential on lipid metabolism as a highly sensitive regulatory pathway and (2) the interference of diesel exhaust particles with toll-like receptor-mediated inflammatory responses. Furthermore, new developments of air-liquid interface exposure used as an alternative approach to simulate cell particle interactions are presented. In addition to the in vitro approaches, animal exposure studies are described that apply selected mouse models to elucidate potential allergic and inflammatory pulmonary responses and mast-cell-related mechanisms after particle exposure. Long-term inhalation of ultrafine particles might lead to irreversible changes in lung structure and function. Clinical studies addressing the characteristics of inflammatory airway cells are a promising approach to understand underlying pathophysiological mechanisms in chronic obstructive pulmonary disease. Finally, a potential outcome of human particle exposure is chronic cough in children. Here, discrimination between asthmatic and nonasthmatic cough by means of immunological parameters appears to be an important step toward improving diagnosis and therapy.
Authors:
Konrad Ludwig Maier; Francesca Alessandrini; Ingrid Beck-Speier; Thomas Philipp Josef Hofer; Silvia Diabaté; Ellen Bitterle; Tobias Stöger; Thilo Jakob; Heidrun Behrendt; Marion Horsch; Johannes Beckers; Axel Ziesenis; Lothar Hültner; Marion Frankenberger; Susanne Krauss-Etschmann; Holger Schulz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Inhalation toxicology     Volume:  20     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-37     Citation Subset:  IM    
Affiliation:
Institute of Inhalation Biology, German Research Center for Environmental Health (GmbH), Germany. kmaier@gsf.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism
Cell Survival / drug effects
Cells, Cultured
Cyclooxygenase 2 / metabolism
Cytokines / metabolism
Disease Models, Animal
Gene Expression Regulation / drug effects
Humans
Inflammation / chemically induced*,  immunology,  metabolism
Inhalation Exposure
Lipid Metabolism
Macrophages, Alveolar / drug effects*,  immunology,  metabolism
Monocytes / drug effects*,  immunology,  metabolism
Oxidation-Reduction
Particle Size
Particulate Matter / adverse effects*
Toll-Like Receptors / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Particulate Matter; 0/Toll-Like Receptors; EC 1.14.99.1/Cyclooxygenase 2

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