Document Detail


Health aspects of chloroform--a review.
MedLine Citation:
PMID:  385279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
First prepared in 1831, chloroform was initially employed as an "ideal" anesthetic. Chloroform was later found to cause heart and liver damage and, with the discovery of safer agents, lost importance as a medical anesthetic. Today chloroform is used primarily as a solvent in industry, in the production of antibiotics, as a cleaning agent, and as an ingredient in pharmaceutical and veterinary formulations. A recent report issued by the National Cancer Institute implicates chloroform as a carcinogen in laboratory rodents. These findings, in conjunction with enforcement of the Delaney Clause have generated renewed interest in chemicals such as chloroform which are not only used in a variety of industrial applications, but which are also available to the general public in a number of food and cosmetic products.
Authors:
S G Winslow; H B Gerstner
Related Documents :
20352329 - Current situation and the development of the dairy industry in jordan, saudi arabia, an...
21652519 - Does living in a food insecure household impact on the diets and body composition of yo...
22063929 - Microbiological safety standards and public health goals to reduce foodborne disease.
21643909 - Lc/tof-ms analysis of pesticides in fruits and vegetables: the emerging role of accurat...
15854709 - Food engineering and predictive microbiology: on the necessity to combine biological an...
21969329 - Identifying fast-food restaurants using a central register as a measure of the food env...
24100549 - Origin and concept of medicine food homology and its application in modern functional f...
14616409 - Effect of food on the pharmacokinetics of multiple-dose oral voriconazole.
7033329 - Factors affecting the bioavailability of zinc.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  1     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1978  
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-75     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens
Chemistry, Physical
Chloroform / metabolism,  toxicity*
Embryo, Mammalian / drug effects
Eye / drug effects
Female
Fetus / drug effects
Heart / drug effects
Humans
Kidney / drug effects
Liver / drug effects
Physicochemical Phenomena
Pregnancy
Respiration / drug effects
Species Specificity
Chemical
Reg. No./Substance:
0/Carcinogens; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Penfluridol: a neuroleptic drug designed for long duration of action.
Next Document:  Comparison of the relative mutagenic activity for eight antineoplastic drugs in the Ames Salmonella/...