Document Detail

Health aspects of chloroform--a review.
MedLine Citation:
PMID:  385279     Owner:  NLM     Status:  MEDLINE    
First prepared in 1831, chloroform was initially employed as an "ideal" anesthetic. Chloroform was later found to cause heart and liver damage and, with the discovery of safer agents, lost importance as a medical anesthetic. Today chloroform is used primarily as a solvent in industry, in the production of antibiotics, as a cleaning agent, and as an ingredient in pharmaceutical and veterinary formulations. A recent report issued by the National Cancer Institute implicates chloroform as a carcinogen in laboratory rodents. These findings, in conjunction with enforcement of the Delaney Clause have generated renewed interest in chemicals such as chloroform which are not only used in a variety of industrial applications, but which are also available to the general public in a number of food and cosmetic products.
S G Winslow; H B Gerstner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  1     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1978  
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-75     Citation Subset:  IM    
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MeSH Terms
Chemistry, Physical
Chloroform / metabolism,  toxicity*
Embryo, Mammalian / drug effects
Eye / drug effects
Fetus / drug effects
Heart / drug effects
Kidney / drug effects
Liver / drug effects
Physicochemical Phenomena
Respiration / drug effects
Species Specificity
Reg. No./Substance:
0/Carcinogens; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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