Document Detail


Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials.
MedLine Citation:
PMID:  21464420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study is an update of a systematic review of health-related quality-of-life (HRQOL) methodology reporting in non-small-cell lung cancer (NSCLC) randomized controlled trials (RCTs). The objective was to evaluate HRQOL methodology reporting over the last decade and its benefit for clinical decision making.
METHODS: A MEDLINE systematic literature review was performed. Eligible RCTs implemented patient-reported HRQOL assessments and regular oncology treatments for newly diagnosed adult patients with NSCLC. Included studies were published in English from August 2002 to July 2010. Two independent reviewers evaluated all included RCTs.
RESULTS: Fifty-three RCTs were assessed. Of the 53 RCTs, 81% reported that there was no significant difference in overall survival (OS). However, 50% of RCTs that were unable to find OS differences reported a significant difference in HRQOL scores. The quality of HRQOL reporting has improved; both reporting of clinically significant differences and statistical testing of HRQOL have improved. A European Organisation for Research and Treatment of Cancer HRQOL questionnaire was used in 57% of the studies. However, reporting of HRQOL hypotheses and rationales for choosing HRQOL instruments were significantly less than before 2002 (P < .05).
CONCLUSION: The number of NSCLC RCTs incorporating HRQOL assessments has considerably increased. HRQOL continues to demonstrate its importance in RCTs, especially in those studies in which no OS difference is found. Despite the improved quality of HRQOL methodology reporting, certain aspects remain underrepresented. Our findings suggest need for an international standardization of HRQOL reporting similar to the CONSORT guidelines for clinical findings.
Authors:
Lily Claassens; Jan van Meerbeeck; Corneel Coens; Chantal Quinten; Irina Ghislain; Elizabeth K Sloan; Xin Shelly Wang; Galina Velikova; Andrew Bottomley
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-04
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  29     ISSN:  1527-7755     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-19     Completed Date:  2011-07-15     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2104-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Non-Small-Cell Lung / psychology*
Health Status
Humans
Lung Neoplasms / psychology*
Outcome Assessment (Health Care) / standards*
Quality of Life*
Randomized Controlled Trials as Topic / methods*
Research Design / standards
Grant Support
ID/Acronym/Agency:
5U10CA011488-39/CA/NCI NIH HHS; 5U10CA011488-40/CA/NCI NIH HHS; 7424//Cancer Research UK
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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