Document Detail

Healing process of skin after CO2 laser ablation at low irradiance: a comparison of continuous-wave and pulsed mode.
MedLine Citation:
PMID:  15782027     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of the present study was to compare the healing process of rabbit's skin after the ablation of continuous wave CO(2) laser and pulsed CO(2) laser at low irradiances. BACKGROUND DATA: Because of its advantages, the CO(2) laser has been viewed as an alternative to the traditional scalpel. Simple thermal models suggest that suitably short pulses of laser irradiation can leave a smaller thermal damaged zone to ablated tissue, which may lead to faster healing. METHODS: One continuous-wave (cw, 2 watt) and two pulsed CO(2) lasers (sp(1), 100 Hz, 2 watt; and sp(2), 25 Hz, 2 watt) were used to ablate twelve rabbits' ear skin for 2 min, respectively. After sacrifice at 0, 3, 7, 14, 28, and 56 days postsurgery, gross observation and histological examination were performed. RESULTS: sp(1) and sp(2) resulted in similar ablation rates to cw laser. At 3, 7, 14, and 28 days postsurgery, the scores of the group cw were significantly lower than both the sp(1) and sp(2) scores (p < 0.01). From 7 to 28 days, wounds of sp1 showed the best histological outcomes. CONCLUSION: At a relatively low irradiance, pulsed CO(2) laser is capable of bloodless skin ablation with improved wound healing. Increasing repetition rate of the CO(2) laser may help to achieve a better surgical outcome. Pulsed CO(2) laser may be a valuable instrument for ablation skin and skin lesions.
Xiaogu Wang; Nelson Tatsunari Ishizaki; Koukichi Matsumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  23     ISSN:  1549-5418     ISO Abbreviation:  -     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-22     Completed Date:  2005-04-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Department of Endodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan.
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MeSH Terms
Carbon Dioxide
Laser Therapy / methods*
Skin / pathology*,  surgery*
Wound Healing*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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