| Healing process of experimental esophageal ulcers induced by acetic acid in rats. | |
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MedLine Citation:
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PMID: 2595309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the healing of acetic acid-induced esophageal ulcers in rats with respect to the cellular kinetics. Esophageal ulcers were induced by topical application of acetic acid to the serosal surface. Well-demarcated circular or elliptical ulcers had developed by day 3 after the acid treatment. These ulcers began to decrease in size from day 7 and had healed by day 14. Histological and cellular kinetic findings, with bromodeoxyuridine (BrdU), were degeneration of the esophageal mucosa on day 1 and ulcer formation on day 3, with an increase in the number of BrdU-labeled cells in the esophageal mucosa around the ulcer. On day 7, regenerated epithelium was found to extend towards the ulcer base and the regenerated epithelium had become thicker, with papilla formation, by day 10. On day 14, the ulcer base was covered with thickened regenerated mucosa, with a decrease in the number of BrdU-labeled cells. Marked proliferative activity of the regenerated mucosa and thickening of the esophageal mucosa, with papilla formation, were observed during the healing process. |
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Authors:
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H Tsuji; Y Fuse; K Kawamoto; H Fujino; T Kodama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 162 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-01-23 Completed Date: 1990-01-23 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 6-10 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Acetic Acids Animals Epithelium / physiopathology Esophageal Diseases / chemically induced, pathology, physiopathology* Male Rats Rats, Inbred Strains Regeneration Stomach / physiopathology Time Factors Ulcer / chemically induced, pathology, physiopathology* Wound Healing* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 64-19-7/Acetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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