| Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics. | |
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MedLine Citation:
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PMID: 20616768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare healing outcomes at a wound healing centre both before and after the introduction of molecular pathogen diagnostics. METHOD: An IT consultant was recruited to analyse the medical records of patients at a wound healing centre, comparing patient groups from 2007 and 2009 - before and after the introduction of comprehensive molecular pathogen diagnostic methods. RESULTS: Before the implementation of molecular diagnostics, 244/503 patients (48.5%) healed completely, while after implementation 298/479 patients (62.4%) healed. Furthermore, based on survival analysis and after controlling for potential confounding factors, time to healing was significantly shorter in 2009 than 2007 (p<0.05). Specifically, biofilm-based wound care, along with the implementation of comprehensive molecular diagnostics for venous leg ulcers, pressure ulcers and diabetic foot ulcers and all wounds combined showed, respectively, 21%, 23%, 25% and 22% reductions in the time to healing. In addition, after implementing molecular diagnostics, the use of expensive fi rst-line antibiotics also declined in 2009, while a broader range of targeted antibiotics was used. CONCLUSION: The results of modern molecular pathogen diagnostic applications allow comprehensive evaluation of the microbial bioburden in chronic wounds. This comprehensive diagnostic in turn has led to a more precise and targeted therapeutic approach to wound care. With the comprehensive nature of molecular diagnostics future advances in topical patient specific therapeutics are now possible. |
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Authors:
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R D Wolcott; S B Cox; S E Dowd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of wound care Volume: 19 ISSN: 0969-0700 ISO Abbreviation: J Wound Care Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417080 Medline TA: J Wound Care Country: England |
Other Details:
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Languages: eng Pagination: 272-8, 280-1 Citation Subset: N |
Affiliation:
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Southwest regional Wound Care CEnter, Lubbock, Texas, USA. randy@randallwolcott.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Analysis of Variance Child Child, Preschool Debridement Diabetic Foot / complications Female Humans Male Middle Aged Pathology, Molecular / methods*, trends Pressure Ulcer / complications Proportional Hazards Models Retrospective Studies Skin Care / methods Survival Analysis Texas Time Factors Treatment Outcome Varicose Ulcer / complications Wound Healing* Wound Infection* / diagnosis, microbiology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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