Document Detail

Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma.
MedLine Citation:
PMID:  23111655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate bone healing in an experimental radial ostectomy in dogs treated with autologous platelet-rich plasma (PRP), through histological, densitometric, radiographic studies, as well as expression of growth factors in the ostectomy gap.
METHODS: Twenty-one dogs were randomly divided into either a control or a PRP group. All underwent unilateral ostectomy of the radius to generate a gap of 2.0 mm, that was stabilized with external skeletal fixation. The ostectomy gap was either filled with PRP or left empty as a control. The radiographic and densitometric studies were performed after surgery, then at intervals until 60 days during the post-surgery period. Histological and immunohistochemical evaluations were performed at seven or 60 days post-surgery. Analyses were performed using a statistical analysis system, and the level of significance was set at p <0.05.
RESULTS: The median radiographic healing score in the PRP group increased significantly between day 0 and day 60. Furthermore, at 60 days, the median healing score and the proportion of healed ostectomies in the control group (score 1; 1/6 healed) and the PRP group (score 5; 4/5 healed) were significantly different. There were differences between groups in radiographic and densitometric values at days 45 and 60. The histological evaluation showed advanced bone healing at 60 days in the PRP group and signs of delayed union in the control group.
CLINICAL RELEVANCE: Platelet-rich plasma can be used as an adjuvant therapy because it may promote better bone healing of a radial ostectomy treated with external skeletal fixation in dogs.
T F B Souza; A L Andrade; G T N M Ferreira; G T N M Ferrreira; S S Sakamoto; V B Albuquerque; S R M Bonfim; M C R Luvizotto; M J Q Louzada
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-10-29
Journal Detail:
Title:  Veterinary and comparative orthopaedics and traumatology : V.C.O.T     Volume:  25     ISSN:  0932-0814     ISO Abbreviation:  Vet Comp Orthop Traumatol     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-29     Revised Date:  2014-06-26    
Medline Journal Info:
Nlm Unique ID:  8906319     Medline TA:  Vet Comp Orthop Traumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  445-52     Citation Subset:  IM    
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MeSH Terms
Absorbable Implants / veterinary
Biomechanical Phenomena
Bone and Bones / physiology*
Fracture Healing / physiology*
Implants, Experimental / veterinary*
Platelet-Derived Growth Factor / genetics,  metabolism*
Platelet-Rich Plasma
Transforming Growth Factor beta1 / genetics,  metabolism*
Transforming Growth Factor beta2 / genetics,  metabolism*
Reg. No./Substance:
0/Platelet-Derived Growth Factor; 0/Transforming Growth Factor beta1; 0/Transforming Growth Factor beta2
Erratum In:
Vet Comp Orthop Traumatol. 2013;26(1):87
Note: Ferrreira, G T N M [corrected to Ferreira, G T N M]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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