| Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 16796640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. AIMS: This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV. METHODS: In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared. RESULTS: The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001). CONCLUSIONS: Pilocarpine gel effectively treats PV. |
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Authors:
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Fariba Iraji; AliReza Yoosefi |
Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 45 ISSN: 0011-9059 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-26 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 743-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, AL-Zahra Hospital, Isfahan University of Medical Sciences, Iran. iraji@med.mui.ac.ir |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholinergic Agents
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administration & dosage,
therapeutic use Double-Blind Method Epithelium / drug effects, pathology Gels Humans Pemphigus / drug therapy*, pathology Pilocarpine / administration & dosage, therapeutic use* Placebos |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Agents; 0/Gels; 0/Placebos; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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