Document Detail


Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris.
MedLine Citation:
PMID:  16796640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. AIMS: This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV. METHODS: In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared. RESULTS: The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001). CONCLUSIONS: Pilocarpine gel effectively treats PV.
Authors:
Fariba Iraji; AliReza Yoosefi
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  45     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-26     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, AL-Zahra Hospital, Isfahan University of Medical Sciences, Iran. iraji@med.mui.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Cholinergic Agents / administration & dosage,  therapeutic use
Double-Blind Method
Epithelium / drug effects,  pathology
Gels
Humans
Pemphigus / drug therapy*,  pathology
Pilocarpine / administration & dosage,  therapeutic use*
Placebos
Chemical
Reg. No./Substance:
0/Cholinergic Agents; 0/Gels; 0/Placebos; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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