Document Detail

Healing of benign gastric ulcer: comparison of cimetidine and placebo in the United States.
MedLine Citation:
PMID:  3885813     Owner:  NLM     Status:  MEDLINE    
Recently the Food and Drug Administration approved cimetidine for the treatment of benign gastric ulcer. Approval was based in part on the results of our large multicenter trial involving 172 patients with benign gastric ulcer between 0.5 and 2.5 cm in diameter: 87 were randomly assigned to receive cimetidine (300 mg four times daily) and 85 to receive placebo. Cimetidine treatment resulted in significantly more rapid healing than placebo; after 2 and 6 weeks of therapy, 10.0% and 44.8% of patients receiving placebo were healed, as compared to 22.6% and 65.1% receiving cimetidine. The results of our study were compared with the time-response curve previously published (0, 4, and 8 weeks of therapy). The combined data yielded linear healing rates for the first 8 weeks of therapy (r greater than 0.99 for both cimetidine and placebo). These studies can be used to define expectations for healing of benign gastric ulcer, and we recommend follow-up intervals of 8 and, if unhealed, 16 weeks.
D Y Graham; K Akdamar; W P Dyck; E Englert; R G Strickland; J L Achord; A A Belsito; Z R Vlahcevic; R N Kornfield; W B Long
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of internal medicine     Volume:  102     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-05-10     Completed Date:  1985-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cimetidine / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Random Allocation
Research Design
Stomach Ulcer / drug therapy*,  pathology
Time Factors
Reg. No./Substance:
0/Placebos; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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