| Healing of benign gastric ulcer: comparison of cimetidine and placebo in the United States. | |
| | |
MedLine Citation:
|
PMID: 3885813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recently the Food and Drug Administration approved cimetidine for the treatment of benign gastric ulcer. Approval was based in part on the results of our large multicenter trial involving 172 patients with benign gastric ulcer between 0.5 and 2.5 cm in diameter: 87 were randomly assigned to receive cimetidine (300 mg four times daily) and 85 to receive placebo. Cimetidine treatment resulted in significantly more rapid healing than placebo; after 2 and 6 weeks of therapy, 10.0% and 44.8% of patients receiving placebo were healed, as compared to 22.6% and 65.1% receiving cimetidine. The results of our study were compared with the time-response curve previously published (0, 4, and 8 weeks of therapy). The combined data yielded linear healing rates for the first 8 weeks of therapy (r greater than 0.99 for both cimetidine and placebo). These studies can be used to define expectations for healing of benign gastric ulcer, and we recommend follow-up intervals of 8 and, if unhealed, 16 weeks. |
| | |
Authors:
|
D Y Graham; K Akdamar; W P Dyck; E Englert; R G Strickland; J L Achord; A A Belsito; Z R Vlahcevic; R N Kornfield; W B Long |
Related Documents
:
|
9261533 - Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions. 7600143 - Efficacy and safety of ebrotidine compared with ranitidine in patients with duodenal ul... 23438283 - Needleless closed system does not reduce central venous catheter-related bloodstream in... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Annals of internal medicine Volume: 102 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1985 May |
Date Detail:
|
Created Date: 1985-05-10 Completed Date: 1985-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 573-6 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cimetidine / therapeutic use* Clinical Trials as Topic Double-Blind Method Female Gastroscopy Humans Male Middle Aged Placebos Random Allocation Research Design Stomach Ulcer / drug therapy*, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Placebos; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Childhood benign chronic bullous dermatosis. Differential diagnosis with dermatitis herpetiformis an...
Next Document: Cryptosporidiosis in hospital personnel. Evidence for person-to-person transmission.