Document Detail


Healing of autogenous intramembranous bone in the presence and absence of homologous demineralized intramembranous bone.
MedLine Citation:
PMID:  10715088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to examine the osteogenecity of demineralized bone matrix (DBM) prepared from intramembranous (IM) bone and to quantitatively assess the amount of new bone formed by IM autogenous bone grafts with or without DBM(IM). Forty-two defects were created in 42 New Zealand White rabbits. Twenty-one defects were grafted with IM bone alone, and the other 21 defects were grafted with composite IM-DBM(IM). Eleven rabbits, 22 defects were used as controls, where 11 defects were left empty (passive control) and the other 11 defects were filled with rabbit skin collagen (active control). Tissues were retrieved on days 1, 2, 3, 4, 5, 6, 7, and 14 for qualitative and quantitative analysis. Cells involved in the healing of composite IM and IM-DBM(IM) bone grafts were identified. No cartilage cells were detected during the healing of either grafts. Appearance of small blood vessels into the newly formed matrix was seen on day 5 in IM bone grafts and on day 4 in composite IM-DBM(IM) bone graft. Quantitative analysis was performed by means of image analysis on 100 sections of tissues retrieved after 14 days. Approximately 204% more new bone was formed in defects grafted with composite IM-DBM(IM) than in those grafted with IM bone alone (P <.0001). No bone was formed across the defects in either active or passive controls. In conclusion, DBM(IM) significantly increases the osteogenicity of IM bone grafts.
Authors:
A B Rabie; S H Chay; A M Wong
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  117     ISSN:  0889-5406     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-11     Completed Date:  2000-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  288-97     Citation Subset:  D; IM; S    
Affiliation:
University of Hong Kong, Hong Kong, Republic of China. rabie@hkusua.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Bone Matrix / blood supply,  pathology
Bone Substitutes / therapeutic use*
Bone Transplantation / methods*,  pathology
Bone and Bones / blood supply,  pathology,  physiopathology,  surgery*
Chondrocytes / pathology
Collagen / therapeutic use
Confidence Intervals
Decalcification Technique
Image Processing, Computer-Assisted
Microscopy, Electron
Neovascularization, Physiologic
Osteoblasts / pathology
Osteocytes / pathology
Osteogenesis / physiology
Rabbits
Transplantation, Autologous
Transplantation, Homologous
Wound Healing
Chemical
Reg. No./Substance:
0/Bone Substitutes; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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