| Healing Large Traumatic Eardrum Perforations in Humans Using Fibroblast Growth Factor Applied Directly or via Gelfoam. | |
| | |
MedLine Citation:
|
PMID: 23150095 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: The goal of this study was to evaluate the effects of conservative treatment and fibroblast growth factor (FGF) applied directly or via Gelfoam on the healing of large traumatic tympanic membrane perforations (TMPs) in humans. STUDY DESIGN: Prospective, randomized, controlled trial. METHODS: A randomized prospective analysis was performed between February 2009 and January 2011 for the treatment of traumatic TMPs in humans that affected greater than 50% of the TM. The closure rate, closure time, hearing gain, and rate of otorrhea were compared among the direct application of FGF, FGF via Gelfoam, and conservative treatment. RESULTS: A total of 94 patients were analyzed. The closure rates of large perforations in the direct FGF application, FGF via Gelfoam, and observation groups were 100%, 97%, and 55%, respectively. FGF-treated groups had significantly improved closure rates compared with the observation group (p < 0.05). However, the closure rate did not differ significantly between patients who received FGF only and those who received FGF via Gelfoam (p > 0.05). FGF-treated groups showed shorter mean closure times compared with the observation group (p < 0.05). However, the closure time did not differ significantly between FGF-treated groups (p > 0.05).All perforations were closed within 2 weeks, regardless of the presence of curled edges in the FGF-treated groups. |
| | |
Authors:
|
Zhengcai Lou |
Related Documents
:
|
9331855 - Transabdominal preperitoneal laparoscopic inguinal herniorrhaphy (tplih) under regional... 9001875 - Antibiotic prophylaxis in umbilical and incisional hernia repair: a prospective randomi... 7807455 - Audit of patients' experiences of cholecystectomy: laparoscopic and open operations com... 20724215 - A biomechanical, histological and biochemical study in an experimental rabbit hypospadi... 12271415 - Persistent non-specific fdg uptake on pet imaging following hip arthroplasty. 10591455 - Surgical treatment of temporomandibular joint luxation. |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology Volume: 33 ISSN: 1537-4505 ISO Abbreviation: Otol. Neurotol. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100961504 Medline TA: Otol Neurotol Country: - |
Other Details:
|
Languages: ENG Pagination: 1553-1557 Citation Subset: - |
Affiliation:
|
Department of Otorhinolaryngology, The Affiliated YiWu Hospital of Wenzhou Medical College, Zhejiang, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cochlear Implantation Via the Middle Fossa Approach: Surgical and Programming Considerations.
Next Document: Association of Benign Intracranial Hypertension and Spontaneous Encephalocele With Cerebrospinal Flu...