| Headache in patients with pituitary adenoma: Clinical and paraclinical findings. | |
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MedLine Citation:
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PMID: 23059488 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim:The aim of this article is to generate hypotheses for the mechanism of pituitary adenoma headache.Patients and methods:Fifty-eight patients with pituitary adenoma were prospectively analysed for prevalence and manifestation of tumour headache. Intrapersonal and neoplasm-associated risk factors were assessed.Results:Twenty-four patients (41%) had tumour-attributed headache, seven had migraine-like, 11 tension-type headache-like headache, and three both. Cluster headache-like headache was found once, and two headaches remained unclassified. Tumour-attributed headache was associated with a positive history of headache (p = 0.03; OR 3.4), nicotine abuse (p < 0.01; OR 4.7), intake of acute headache medication (p = 0.04; OR 3.3), and a higher tumour proliferation indicated by a Ki67-labelling index (LI) >3% (p = 0.02; OR 11.0). For patients with migraine-like tumour-attributed headache, risk factors were younger age (p = 0.02), nicotine abuse (p < 0.01; OR 10.9), acute headache treatment (p < 0.01; OR 9.0), and Ki67-LI >3% (p = 0.03; OR 14.1). For tension-type headache-like headache, the main risk factor was a positive history of tension-type headache (p = 0.045; OR 5.6).Conclusion:Headache predisposition and local tumour effects might be important for the pathophysiology of pituitary adenoma headache and tumour headache in general. |
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Authors:
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Christoph J Schankin; Anna K Reifferscheid; Markus Krumbholz; Jennifer Linn; Walter Rachinger; Sigrid Langer; Petra Sostak; Thomas Arzberger; Hans Kretzschmar; Andreas Straube |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: - ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurology, University of Munich Hospital - Großhadern, Munich, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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